L. C. Kam

Plasma membrane abundance dictates phagocytic capacity and functional crosstalk in myeloid cells

This study shows that plasma membrane abundance regulates phagocytic capacity and post-phagocytic migration in myeloid cells, with G{beta}4 deficiency leading to increased phagocytosis and altered trafficking.

Mechanically active integrins direct cytotoxic secretion at the immune synapse

This study identifies integrin mechanotransduction as essential for directing cytotoxic secretion at the immune synapse, showing that mechanical forces from LFA-1 guide lytic granule fusion and cytotoxicity.

Centrioles control the capacity, but not the specificity, of cytotoxic T cell killing

This study shows that centrioles affect the capacity but not the specificity of cytotoxic T cell killing by impacting granule biogenesis and actin remodeling, not granule polarization.

Synapse propensity of human memory CD8 T cells confers competitive advantage over naïve counterparts

The paper shows human memory CD8 T cells have higher synapse propensity than naive cells, giving them competitive advantage in immune responses.

Interfacial actin protrusions mechanically potentiate killing by cytotoxic T cells

Cytotoxic T cells use actin-rich protrusions at immunological synapses to enhance perforin and granzyme-mediated killing of target cells.