X. Ju

Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication

This study identifies the role of G3BP1-N interaction in SARS-CoV-2 replication by showing that disrupting this interaction reduces viral replication and pathogenesis.

Incomplete transcripts dominate the Mycobacterium tuberculosis transcriptome

This study profiles the Mtb transcriptome using SEnd-seq and finds that incomplete transcripts dominate due to low transcription processivity and transcription-translation coupling.

Head-on and co-directional RNA polymerase collisions orchestrate bidirectional transcription termination

This study shows that RNA polymerase collisions in E. coli regulate bidirectional transcription termination through head-on and co-directional interactions.

Distinct denitrifying phenotypes of predominant bacteria mould nitrous oxide metabolism in upland agricultural soils

The paper investigates N2O emissions in two agricultural soils by analyzing denitrifying bacterial communities and their metabolic phenotypes, finding that differences in bacterial composition and gene function drive variations in N2O accumulation.

Inhibition of SAR S-CoV-2 infection and replication by lactoferrin, MUC1 and α-lactalbumin identified in human breastmilk

This study identifies lactoferrin, MUC1, and α-lactalbumin in human breastmilk as antiviral components that inhibit SARS-CoV-2 infection and replication, including variants.

Characterization of SARS-CoV-2 variants B.1.617.1 (Kappa), B.1.617.2 (Delta) and B.1.618 on cell entry, host range, and sensitivity to convalescent plasma and ACE2 decoy receptor

This study characterizes SARS-CoV-2 variants Kappa, Delta, and B.1.618, finding increased ACE2 binding in non-human hosts, enhanced spike cleavage, and reduced neutralization sensitivity, but maintained sensitivity to ACE2 decoy receptor.

Mutation Y453F in the spike protein of SARS-CoV-2 enhances interaction with the mink ACE2 receptor for host adaption

This study identifies the Y453F mutation in SARS-CoV-2 spike protein as enhancing binding to mink ACE2 while maintaining human ACE2 utilization, highlighting its role in host adaptation.

Analysis of viral RNA-host protein interactomes enables rapid antiviral drug discovery

The paper identifies antiviral drugs by analyzing RNA-host protein interactomes of SARS-CoV-2, EBOV, and ZIKV.

A novel cell culture system modeling the SARS-CoV-2 life cycle

This paper develops a BSL-2 cell culture system for producing SARS-CoV-2 virus-like particles to enable safe antiviral screening and life cycle studies.

Comparison of induced neurons reveals slower structural and functional maturation in humans than in apes

This study compares the maturation of induced neurons from chimpanzee, bonobo, and human stem cells, finding slower structural and functional development in humans.

Listeria monocytogenes personalized cancer vaccines drive therapeutic immune responses to cancer derived neoantigens

This study demonstrates that ADXS-NEO, a personalized Listeria monocytogenes vaccine, effectively targets tumor-specific mutations and controls tumor growth in mice by inducing neoantigen-specific T cell responses.

Functional and Genetic Analysis of Viral Receptor ACE2 Orthologs Reveals a Broad Potential Host Range of SARS-CoV-2

This study identifies ACE2 orthologs from diverse species that can support SARS-CoV-2 entry, suggesting a broad host range for the virus.