Author

S. Ehrt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 9 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:drug response / drug discovery· 6 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Approach:genetic perturbation / CRISPR· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

D. Schnappinger· 9 shared T. R. Ioerger· 4 shared C. M. Sassetti· 3 shared C. Trujillo· 3 shared H. Su· 3 shared K. Lin· 3 shared K. M. Guinn· 3 shared K. Y. Rhee· 3 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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9 shared papersMicrobiology

D. Schnappinger

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

A "suicide" BCG strain provides enhanced immunogenicity and robust protection against Mycobacterium tuberculosis in macaques

A. A. Smith, H. Su, J. Wallach, Y. Liu, P. Maiello, H. J. Borish, C. Winchell, A. W. Simonson, P. L. Lin, M. Rodgers, D. J. Filmore, J. Sakal, K. Lin, V. Vinette, D. Schnappinger, , J. L. Flynn

This study develops a 'suicide' BCG strain that is safely eliminated in immunocompromised hosts but induces stronger immune responses and better protection against Mtb in macaques.

bioRxiv · Nov 22, 2023 · PreprintImmunology

Development of an Engineered Mycobacterium tuberculosis Strain for a Safe and Effective Tuberculosis Human Challenge Model

X. Wang, H. Su, J. B. Wallach, J. C. Wagner, B. J. Braunecker, M. Gardner, K. M. Guinn, T. Klevorn, K. Lin, Y. J. Liu, Y. Liu, D. Mugahid, M. Rodgers, J. Sixsmith, S. Wakabayashi, , D. Schnappinger

This paper develops an engineered Mycobacterium tuberculosis strain with kill switches for a safe TB human challenge model, showing rapid clearance and low escape rates.

bioRxiv · Nov 19, 2023 · PreprintMicrobiology

Synthetic lethality of Mycobacterium tuberculosis NADH dehydrogenases is due to impaired NADH oxidation

Y. Xu, S. Ehrt, D. Schnappinger, T. Beites

The paper investigates synthetic lethality in Mycobacterium tuberculosis by showing that simultaneous inactivation of Ndh-1 and Ndh-2 NADH dehydrogenases leads to bacterial death due to impaired NADH oxidation.

bioRxiv · Apr 10, 2023 · PreprintMicrobiology

Cyclic AMP is a critical mediator of intrinsic drug resistance and fatty acid metabolism in M. tuberculosis

A. I. Wong, T. Beites, K. A. Planck, S. Li, N. C. Poulton, K. Rhee, D. Schnappinger, S. Ehrt, J. M. Rock

This study identifies cAMP as a key mediator of intrinsic drug resistance and fatty acid metabolism in M. tuberculosis by analyzing the role of the essential adenylate cyclase Rv3645.

bioRxiv · Jul 7, 2022Microbiology

Reliable detection of pyrazinamide antitubercular activity in vitro.

A. Gouzy, C. F. Healy, D. Schnappinger, S. Ehrt

This study demonstrates a reliable method to detect pyrazinamide activity in vitro using an acidic, lipid-rich medium that mimics Mtb infection conditions.

bioRxiv · May 22, 2022 · PreprintMicrobiology

Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection

T. Beites, R. S. Jansen, R. Wang, A. Jinich, K. Y. Rhee, D. Schnappinger, S. Ehrt

This study identifies EtfDMtb as an essential dehydrogenase for fatty acid β-oxidation in Mtb, showing that disrupting it kills the bacterium in vitro and in mice.

bioRxiv · Apr 19, 2021Microbiology

Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy

E.-I. Koh, P. O. Oluoch, N. Ruecker, M. K. Proulx, V. Soni, K. C. Murphy, K. G. Papavinasasundaram, C. J. Reames, C. Trujillo, A. Zaveri, M. D. Zimmerman, R. Aslebagh, R. E. Baker, S. A. Shaffer, K. M. Guinn, , C. M. Sassetti

This study maps chemical-genetic interactions in Mycobacterium tuberculosis to identify how carbon metabolism and cell wall structure affect drug efficacy, revealing environment-dependent and -independent interactions.

bioRxiv · Apr 8, 2021Microbiology

The Mycobacterium tuberculosis transposon sequencing database (MtbTnDB): a large-scale guide to genetic conditional essentiality

A. Jinich, A. Zaveri, M. A. DeJesus, E. Flores-Bautista, R. Almada-Monter, C. M. Smith, C. M. Sassetti, J. M. Rock, S. Ehrt, D. Schnappinger, T. R. Ioerger, K. Y. Rhee

The paper builds MtbTnDB, a database of Mtb TnSeq screens, enabling comparison of genetic essentiality across conditions and analysis of gene function.

bioRxiv · Mar 5, 2021 · PreprintMicrobiology

Genetic models of latent tuberculosis in mice reveal differential control by adaptive immunity

H. Su, K. Lin, D. Tiwari, C. Healy, C. Trujillo, Y. Liu, T. R. Ioerger, D. Schnappinger, S. Ehrt

This study develops genetic mouse models of latent tuberculosis, revealing that adaptive immunity differentially controls relapse depending on the model used.

bioRxiv · Feb 8, 2021Microbiology

Large-scale chemical-genetics yields new Mycobacterium tuberculosis inhibitor classes

E. O. Johnson, E. LaVerriere, M. Stanley, E. Office, E. Meyer, T. Kawate, J. Gomez, R. E. Audette, N. Bandyopadhyay, N. Betancourt, K. Delano, I. Da Silva, J. Davis, C. Gallo, M. Gardner, , Schnappinge

This study uses a novel chemical-genetics screening strategy to identify new inhibitors of Mycobacterium tuberculosis, revealing novel compound classes targeting previously unexplored bacterial targets.

bioRxiv · Jan 16, 2019Microbiology