Author

J. Purushotham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Organism:rat· 2 Assay:spatial transcriptomics· 1

Frequent Co-Authors

J. Schulz· 3 shared T. Lambe· 3 shared V. Munster· 3 shared A. Flaxman· 2 shared A. Okumura· 2 shared A. Spencer· 2 shared C. Gilbride· 2 shared G. Saturday· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

J. Schulz

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Potent immunogenicity and protective efficacy of a multi-pathogen vaccination targeting Zaire ebolavirus, Sudan ebolavirus, Marburg and Lassa viruses

A. Flaxman, S. Sebastian, S. Appelberg, K. Cha, M. Ulaszewska, J. Purushotham, C. Gilbride, H. Sharpe, A. Spencer, S. Bibi, D. Wright, S. Dowall, L. Easterbrook, S. Findlay-Wilson, S. Gilbert, , T. Lambe

This paper develops a multi-pathogen vaccine targeting Zaire ebolavirus, Sudan ebolavirus, Marburg and Lassa viruses, showing strong immunogenicity and protective efficacy in animal models.

bioRxiv · Nov 3, 2023 · PreprintImmunology

Western diet increases COVID-19 disease severity in the Syrian hamster

J. R. Port, D. R. Adney, B. Schwarz, J. Schulz, D. E. Sturdevant, B. J. Smith, V. Avanzato, M. G. Holbrook, J. Purushotham, K. A. Stromberg, I. Leighton, C. Bosio, C. Shaia, V. Munster

This study shows that a Western diet worsens COVID-19 outcomes in Syrian hamsters by increasing weight loss, lung damage, and systemic inflammation.

bioRxiv · Jun 17, 2021 · PreprintMicrobiology

Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces shedding of SARS-CoV-2 D614G in rhesus macaques

N. van Doremalen, J. Purushotham, J. Schulz, M. Holbrook, T. Bushmaker, A. Carmody, J. Port, K. C. Yinda, A. Okumura, G. Saturday, F. Amanat, F. Krammer, P. Hanley, B. Smith, J. Lovaglio, , V. Munster

This study shows intranasal ChAdOx1 nCoV-19 vaccination reduces SARS-CoV-2 shedding in animal models but not pneumonia protection.

bioRxiv · Jan 9, 2021 · PreprintMicrobiology

ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques

N. van Doremalen, T. Lambe, A. Spencer, S. Belij-Rammerstorfer, J. Purushotham, J. Port, V. Avanzato, T. Bushmaker, A. Flaxman, M. Ulaszewska, F. Feldmann, E. Allen, H. Sharpe, J. Schulz, M. Holbrook, , V. Munster

This study shows that the ChAdOx1 nCoV-19 vaccine reduces SARS-CoV-2 viral load and prevents pneumonia in rhesus macaques without causing immune-enhanced disease.

bioRxiv · May 13, 2020 · PreprintMicrobiology