Author

A. Flaxman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:drug response / drug discovery· 2 Organism:virus· 2 Organism:mouse· 1 Organism:rat· 1

Frequent Co-Authors

T. Lambe· 3 shared A. J. Mentzer· 2 shared A. Pauvolid-Correa· 2 shared A. Spencer· 2 shared A. Tuekprakhon· 2 shared B. - Wang· 2 shared C. Dold· 2 shared C. F. da Costa· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersMicrobiology

T. Lambe

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Potent immunogenicity and protective efficacy of a multi-pathogen vaccination targeting Zaire ebolavirus, Sudan ebolavirus, Marburg and Lassa viruses

A. Flaxman, S. Sebastian, S. Appelberg, K. Cha, M. Ulaszewska, J. Purushotham, C. Gilbride, H. Sharpe, A. Spencer, S. Bibi, D. Wright, S. Dowall, L. Easterbrook, S. Findlay-Wilson, S. Gilbert, , T. Lambe

This paper develops a multi-pathogen vaccine targeting Zaire ebolavirus, Sudan ebolavirus, Marburg and Lassa viruses, showing strong immunogenicity and protective efficacy in animal models.

bioRxiv · Nov 3, 2023 · PreprintImmunology

Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

W. Dejnirattisai, J. Huo, D. Zhou, J. Zahradni_k, P. Supasa, C. Liu, H. M. E. Duyvesteyn, H. Ginn, A. J. Mentzer, A. Tuekprakhon, R. Nutalai, B. - Wang, A. Dijokaite, S. Khan, O. Avinoam, , Mad

This study shows that Omicron-B.1.1.529 has extensive mutations in Spike that reduce neutralization by antibodies from vaccinated and previously infected individuals, and escape most monoclonal antibodies.

bioRxiv · Dec 3, 2021 · PreprintMicrobiology

Antibody evasion by the Brazilian P.1 strain of SARS-CoV-2

W. - Dejnirattisai, D. - Zhou, P. - Supasa, C. - Liu, A. J. Mentzer, H. M. Ginn, Y. - Zhao, H. M. E. Duyvesteyn, A. Tuekprakhon, R. Nutalai, B. - Wang, G. C. Paesen, C. - Lopez-Camacho, J. - Slon-Campos, T. Walter, , Barne

This study compares antibody resistance of SARS-CoV-2 variants P.1, B.1.351, and B.1.1.7, finding P.1 is less resistant to antibodies despite similar ACE2 binding mutations.

bioRxiv · Mar 12, 2021Microbiology

ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques

N. van Doremalen, T. Lambe, A. Spencer, S. Belij-Rammerstorfer, J. Purushotham, J. Port, V. Avanzato, T. Bushmaker, A. Flaxman, M. Ulaszewska, F. Feldmann, E. Allen, H. Sharpe, J. Schulz, M. Holbrook, , V. Munster

This study shows that the ChAdOx1 nCoV-19 vaccine reduces SARS-CoV-2 viral load and prevents pneumonia in rhesus macaques without causing immune-enhanced disease.

bioRxiv · May 13, 2020 · PreprintMicrobiology