Author

J. Sakai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

J. Yang· 2 shared M. Akkoyunlu· 2 shared A. Okamoto· 1 shared C. E. Bryant· 1 shared C. G. Proud· 1 shared C. Soriani· 1 shared C. Zorbas· 1 shared C.-K. Chou· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersImmunology

J. Yang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

IL-6 suppresses vaccine responses in neonatal mice by enhancing IL-2 activity on T follicular helper cells

S. Parvathaneni, J. Yang, L. Lotspeich-Cole, J. Sakai, R. C. Lee, M. Akkoyunlu

This study shows IL-6 suppresses TFH cell responses in neonatal mice by enhancing IL-2 activity, while IL-6 deficiency improves vaccine responses.

bioRxiv · Oct 31, 2022 · PreprintImmunology

B cell receptor induced IL-10 production from neonatal CD19+CD43- cells depends on STAT5 mediated IL-6 secretion

J. Sakai, J. Yang, C.-K. Chou, W. Wu, M. Akkoyunlu

This study shows neonatal CD19+CD43- B cells produce IL-10 via STAT5-mediated IL-6 secretion upon BCR activation, revealing a novel mechanism for IL-10 production in neonates.

bioRxiv · Sep 18, 2022Immunology

Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors

M. Pan, C. Zorbas, M. Sugaya, K. Ishiguro, M. Kato, M. Nishida, H. Zhang, M. M. Candeias, A. Okamoto, T. Ishikawa, T. Soga, H. Aburatani, J. Sakai, Y. Matsumura, T. Suzuki, , T. Osawa

The paper shows that glutamine deficiency in cancer cells prevents p53 activation by rRNA synthesis inhibitors, promoting survival during nutrient stress.

bioRxiv · Dec 3, 2021 · PreprintCancer Biology

Criticality of plasma membrane lipids reflects activation state of macrophage cells

E. Cammarota, C. Soriani, R. Taub, F. Morgan, J. Sakai, S. Veatch, C. E. Bryant, P. Cicuta

The paper examines how macrophage plasma membrane lipid composition changes in response to inflammatory stimuli, showing that proximity to a critical point affects membrane protein activity.

bioRxiv · Jun 23, 2019Biophysics