Author

J. Uniacke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Assay:multiome· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Brumwell· 1 shared A. Koromilas· 1 shared B.-J. Guan· 1 shared C. Patsis· 1 shared D. Dieters-Castator· 1 shared D. F. Quail· 1 shared E. J. Specker· 1 shared G. M. Siegers· 1 shared

Activity by Year

2019-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCancer Biology

A. Brumwell

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2 papers

Recent·Most cited

DEAD-box protein family member DDX28 is a negative regulator of HIF-2α and eIF4E2-directed hypoxic translation

S. L. Evagelou, O. Bebenek, E. J. Specker, J. Uniacke

This study identifies DDX28 as a negative regulator of HIF-2α and eIF4E2-directed hypoxic translation, showing its tumor suppressor role by repressing oncogenic mRNA translation in hypoxia.

bioRxiv · May 9, 2019Biochemistry

Translational control of breast cancer plasticity

M. Jewer, L. Lee, G. Zhang, J. Liu, S. D. Findlay, K. M. Vincent, K. Tandoc, D. Dieters-Castator, D. F. Quail, I. Dutta, M. Coatham, Z. Xu, B.-J. Guan, M. Hatzoglou, A. Brumwell, , L.-M. Postovit

The paper identifies hypoxia and drug-induced translational activation of NANOG, SNAIL, and NODAL isoforms that drive breast cancer plasticity and stem-cell-like phenotypes, with potential therapeutic implications.

bioRxiv · Apr 2, 2019Cancer Biology