Author

V. Le Sage

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 12

Signature Assays, Organisms & Methods

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Approach:experimental assay· 11 Research Focus:host-pathogen & immune response· 10 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Organism:human· 3 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

S. Lakdawala· 5 shared A. J. French· 4 shared J. E. Jones· 4 shared S. S. Lakdawala· 4 shared M. M. Myerburg· 3 shared A. Bhagwat· 2 shared E. Nturibi· 2 shared G. H. Padovani· 2 shared

Activity by Year

2019-2024 · peak 4/yr

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10 top collaborators · 30 mutual co-author links

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5 shared papersMicrobiology

S. Lakdawala

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12 papers

Recent·Most cited

Disruption of Herpes Simplex Virus Type 2 pUL21 Phosphorylation Impairs Secondary Envelopment of Cytoplasmic Nucleocapsids

R. L. Finnen, J. H. Muradov, V. Le Sage, B. Banfield

This paper identifies phosphorylation sites in HSV-2 pUL21 and shows that phosphorylation is required for secondary envelopment of nucleocapsids and virus replication.

bioRxiv · Apr 10, 2024Microbiology

Potential pandemic risk of circulating swine H1N2 influenza viruses

V. Le Sage, N. C. Rockey, K. R. McCarthy, A. J. French, M. J. Shephard, R. McBride, J. E. Jones, S. G. Walter, J. D. Doyle, L. Xu, D. J. Barbeau, S. Wang, S. A. Frizzell, L. H. Rigatti, M. M. Myerburg, , S. S. Lakdawala

The paper assesses the pandemic risk of swine H1N2 influenza viruses by analyzing their transmission potential and immune response in ferrets.

bioRxiv · Jan 5, 2024Microbiology

Ventilation does not affect influenza virus transmission efficiency in a ferret playpen setup

N. C. Rockey, V. Le Sage, M. Shephard, N. Vargas-Maldonado, A. J. French, S. Walter, L. M. Ferreri, K. E. Holmes, D. VanInsberghe, H. Clack, A. J. Prussin, A. C. Lowen, L. Marr, S. Lakdawala

This study shows that ventilation rates do not affect influenza virus transmission efficiency in a ferret playpen setup with close-range interactions and fomites.

bioRxiv · Dec 26, 2023 · PreprintMicrobiology

A protective and broadly binding antibody class engages the influenza virus hemagglutinin head at its stem interface

H. C. Simmons, J. Finney, R. Kotaki, Y. Adachi, A. P. Moseman, A. Watanabe, S. Song, L. R. Robinson-McCarthy, V. Le Sage, M. Kuraoka, E. A. Moseman, G. Kelsoe, Y. Takahashi, K. R. McCarthy

This paper identifies a class of human antibodies that bind a conserved HA head-stem interface epitope, offering broad protection against influenza A serotypes in mice.

bioRxiv · Dec 13, 2023Microbiology

Influenza infected macrophages release viral ribonucleoproteins that shape the local host response

S. Fritzlar, S. Lakdawala, J. A. Roberts, L. J. M. Coin, Y.-M. Deng, J. Moselen, V. Le Sage, J. Mackenzie, L. Labzin, A. G. Brooks, P. Reading, S. Londrigan

This study shows that influenza-infected macrophages release viral ribonucleoproteins (vRNPs) that trigger inflammatory responses in uninfected cells through the RIG-I/MDA5 pathway.

bioRxiv · Dec 4, 2023 · PreprintMicrobiology

Detection of Influenza virus and Streptococcus pneumoniae in air sampled from co-infected ferrets and analysis of their influence on pathogen stability

A. J. French, N. Rockey, V. Le Sage, K. Mueller Brown, M. Shephard, S. Frizzell, M. M. Myerburg, N. L. Hiller, S. Lakdawala

This study detects influenza virus and Streptococcus pneumoniae in air samples from co-infected ferrets and assesses their impact on pathogen stability in expelled droplets.

bioRxiv · Feb 24, 2023 · PreprintMicrobiology

Robustness of the ferret model for influenza risk assessment studies: a cross-laboratory exercise

J. A. Belser, E. H. Lau, W. Barclay, I. G. Barr, H. Chen, R. A. Fouchier, M. Hatta, S. Herfst, Y. Kawaoka, S. S. Lakdawala, L. Y. Y. Lee, G. Neumann, M. Peiris, D. R. Perez, C. J. Russell, , K. M. Septer

This study evaluates the consistency of ferret transmission experiments across laboratories for two H1N1 influenza viruses, finding concordant results and suggesting a minimum of three to five labs for reliable risk assessment.

bioRxiv · Apr 2, 2022Microbiology

Pre-existing immunity provides a barrier to airborne transmission of influenza viruses

S. Lakdawala, V. Le Sage, J. Jones, K. Kormuth, W. Fitzsimmons, E. Nturibi, G. Padovani, C. Arevalo, A. French, A. Avery, R. Manivanh, E. E. McGrady, A. Bhagwat, A. S. Lauring, S. E. Hensley

The paper shows that pre-existing non-neutralizing immunity in ferrets blocks airborne transmission of seasonal influenza viruses.

PLOS Pathogens · Feb 18, 2021Peer-reviewedMicrobiology

Parallel evolution between genomic segments of seasonal human influenza viruses reveals RNA-RNA relationships

J. E. Jones, V. Le Sage, G. H. Padovani, M. Calderon, E. S. Wright, S. Lakdawala

This study identifies RNA-RNA interactions in seasonal human influenza viruses by analyzing parallel evolution between genomic segments, revealing coevolution patterns not explained by protein sequence alone.

bioRxiv · Jan 14, 2021Microbiology

Coinfection of Streptococcus pneumoniae reduces airborne transmission of influenza virus

K. Mueller Brown, V. Le Sage, A. J. French, J. E. Jones, G. H. Padovani, A. J. Avery, M. M. Myerburg, S. Schultz-Cherry, J. W. Rosch, N. L. Hiller, S. S. Lakdawala

This study shows that coinfection with Streptococcus pneumoniae reduces airborne transmission of influenza virus by decreasing viral shedding in the upper respiratory tract of ferrets.

bioRxiv · Nov 10, 2020Microbiology

Differentiating the Roles of UL16, UL21 and Us3 in the Nuclear Egress of Herpes Simplex Virus Capsids

J. Gao, R. L. Finnen, M. R. Sherry, V. Le Sage, B. W. Banfield

This study investigates the roles of pUL16, pUL21, and pUs3 in HSV-2 nuclear egress, revealing distinct functions for pUL16 and a novel role for pUL21 in regulating NEC activity.

Journal of Virology · Jun 16, 2020Peer-reviewedMicrobiology

Altered Nucleoprotein Binding to Influenza Virus RNA Impacts Packaging Efficiency and Replication

V. Le Sage, J. P. Kanarek, E. Nturibi, A. V. Nanni, D. J. Snyder, V. S. Cooper, S. S. Lakdawala, N. Lee

This study shows that changes in one influenza virus RNA segment's nucleotide sequence can alter NP binding across the entire genome, impacting replication efficiency.

bioRxiv · May 24, 2019 · PreprintMicrobiology