Author

N. D. Udeshi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 2 Physiology· 2 Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 9 Approach:experimental assay· 8 Organism:human· 5 Research Focus:cell type annotation· 4 Research Focus:protein folding & dynamics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell-cell communication· 2 Research Focus:development & morphogenesis· 2

Frequent Co-Authors

S. A. Carr· 8 shared A. Y. Ting· 5 shared T. Svinkina· 4 shared C. Xu· 3 shared M. E. Olive· 3 shared N. Perrimon· 3 shared E. J. Bergstrom· 2 shared I. A. Droujinine· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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8 shared papersCell Biology

S. A. Carr

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Author profile →

9 papers

Recent·Most cited

Dynamic mapping of proteome trafficking within and between living cells by TransitID

W. Qin, J. S. Cheah, C. Xu, J. Messing, B. D. Freibaum, S. Boeynaems, J. P. Taylor, N. D. Udeshi, S. A. Carr, A. Y. Ting

TransitID maps proteome trafficking between cellular compartments and between cells with nanometer resolution, revealing new roles for stress granules and intercellular signaling.

bioRxiv · Feb 7, 2023Cell Biology

A genetic model for in vivo proximity labeling of the mammalian secretome

R. Yang, A. S. Meyer, I. A. Droujinine, N. D. Udeshi, Y. Hu, J. Guo, J. A. McMahon, D. K. Carey, C. Xu, Q. Fang, J. Sha, S. Qin, D. Rocco, J. Wohlschlegel, A. Y. Ting, , A. P. McMahon

This paper introduces a genetic mouse model for in vivo proximity labeling of the secretome, revealing organ-specific secretory profiles and serum trafficking.

bioRxiv · Apr 13, 2022Cell Biology

Arginine-dependent hypusination of the eukaryotic translation initiation factor (eIF)5A drives erythroid lineage differentiation

P. Gonzalez-Menendez, I. Phadke, M. E. Olive, K. L. McGraw, J. Platon, J. Papoin, H. Yan, M. Daumur, F. Paul, R. Mirmira, A. Joly, J. Galtier, A. Narla, G. Cartron, V. Dardalhon, , N. Taylor

The paper shows that arginine metabolism via hypusination of eIF5A regulates erythroid differentiation and that impaired eIF5A activity leads to erythroid disorders.

bioRxiv · Mar 21, 2022 · PreprintPhysiology

MONTE enables serial immunopeptidome, ubiquitylome, proteome, phosphoproteome, acetylome analyses of sample-limited tissues

J. G. Abelin, E. J. Bergstrom, H. B. Taylor, K. D. Rivera, S. Klaeger, C. Xu, C. J. White, M. E. Olive, M. Maynard, M. H. Kane, S. Rachimi, D. R. Mani, M. A. Gillette, K. R. Clauser, N. D. Udeshi, S. A. Carr

MONTE enables serial multi-omic analysis of immunopeptidome, ubiquitylome, proteome, phosphoproteome, and acetylome from the same tissue samples, preserving precious human material and identifying immunotherapeutic targets.

bioRxiv · Jun 22, 2021 · PreprintCancer Biology

Automating UbiFast for High-throughput and Multiplexed Ubiquitin Enrichment

K. D. Rivera, M. E. Olive, E. J. Bergstrom, A. J. Nelson, K. A. Lee, S. Satpathy, S. A. Carr, N. D. Udeshi

The paper automates the UbiFast method to enable high-throughput, multiplexed ubiquitylation profiling, identifying ~20,000 sites from 500 g input in ~2 hours with improved reproducibility and scalability.

bioRxiv · Apr 28, 2021Biochemistry

Split-TurboID enables contact-dependent proximity labeling in cells

K. F. Cho, T. C. Branon, S. Rajeev, T. Svinkina, N. D. Udeshi, T. Thoudam, C. Kwak, H.-W. Rhee, I.-K. Lee, S. A. Carr, A. Y. Ting

Split-TurboID enables proximity labeling at organelle contact sites by splitting the TurboID enzyme and reconstituting it at these sites, identifying over 100 endogenous proteins.

Proceedings of the National Academy of Sciences · May 18, 2020Peer-reviewedCell Biology

Proteomics of protein trafficking by in vivo tissue-specific labeling

I. A. Droujinine, D. Wang, Y. Hu, N. D. Udeshi, L. Mu, T. Svinkina, R. Zeng, T. Branon, A. Tabatabai, J. A. Bosch, J. M. Asara, A. Y. Ting, S. A. Carr, N. Perrimon

The paper develops an in vivo platform to study secreted protein trafficking between organs, identifies interorgan communication factors, and finds conserved adipokines affecting muscle activity.

bioRxiv · Apr 15, 2020Physiology

UbiFast, a rapid and deep-scale ubiquitylation profiling approach for biology and translational research

N. D. Udeshi, D. Mani, S. Satpathy, S. Fereshetian, J. Gasser, T. Svinkina, B. Ebert, P. Mertins, S. A. Carr

UbiFast enables rapid, high-throughput ubiquitylation profiling of up to 10,000 sites from small tissue samples, with applications in cancer research.

bioRxiv · Sep 27, 2019Biochemistry

Directed evolution of TurboID for efficient proximity labeling in living cells and organisms

T. C. Branon, J. A. Bosch, A. D. Sanchez, N. D. Udeshi, T. Svinkina, S. A. Carr, J. L. Feldman, N. Perrimon, A. Y. Ting

The paper develops TurboID and miniTurbo, biotin ligase mutants with enhanced catalytic efficiency for proximity labeling in cells and organisms, significantly reducing labeling time and toxicity.

bioRxiv · Oct 2, 2017Bioengineering