J. Yao

This paper creates a single-cell transcriptomic atlas of the Chinese horseshoe bat to study its role as a viral reservoir, identifying cell types and receptor expression patterns related to viral entry.

This study identifies therapy-induced transdifferentiation as a mechanism of EGFR-targeted therapy resistance in gliomas, independent of EGFR signaling, and suggests combinatorial therapies targeting both EGFR and transdifferentiation pathways.

This paper develops a transferable and interpretable deep learning model for MSI prediction from histopathology images, achieving high AUC scores in two cohorts.

The paper shows that Brassica tournefortii uses different KAI2 homologues to respond to KAR1, while Arabidopsis thaliana prefers KAR2, with two amino acid variants explaining ligand selectivity.

The paper shows IGF2BP proteins rapidly cluster under osmotic stress, initiating stress granule formation before other proteins, and identifies the molecular mechanisms involved.

This study identifies CIC as a critical regulator of neuronal differentiation by repressing VGF expression through a corepressor complex, linking its dysfunction to brain tumor development.

This study identifies YAP1 as a context-specific driver for the squamous subtype of pancreatic ductal adenocarcinoma and shows WNT5A promotes tumor progression through YAP1 activation.

The paper identifies distinct miRNA sorting mechanisms in cancer cell-derived extracellular vesicles, showing selective and non-selective pathways mediated by Lupus La and miR-122 motifs.

The paper introduces the BioCompute framework to standardize genomic data reporting, enabling reproducibility and interoperability in precision medicine.

The paper identifies distinct microbial, metabolic, and ecological differences between deficient and proficient mismatch repair colorectal cancers using microbiome and metabolomic analyses.

The paper uses TGIRT-seq to analyze RNA in exosomes, revealing that YBX1 influences the sorting of small non-coding RNAs like tRNAs and Y RNAs into exosomes.