Jean‐Martin Beaulieu

Fluoxetine-induced neurogenesis and chronic antidepressant effects requires the dopamine D2 receptor.

This study shows that chronic fluoxetine's antidepressant effects and neurogenesis require the dopamine D2 receptor, with implications for treatment response and drug interactions.

Combination of Haloperidol with UNC9994, β-arrestin-biased analog of Aripiprazole, ameliorates schizophrenia-related phenotypes induced by NMDAR deficit in mice.

This study shows that combining haloperidol with UNC9994 reduces schizophrenia-like symptoms in NMDAR-deficient mice.

A miR-137-related biological pathway of risk for Schizophrenia is associated with human brain emotion processing

The paper links miR-137 and its target genes to schizophrenia risk through emotion processing in the prefrontal cortex, showing allele associations with brain activation patterns.

Characterization of mitochondrial health from human peripheral blood mononuclear cells to cerebral organoids derived from induced pluripotent stem cells

The paper develops cerebral organoids from iPSCs derived from PBMCs to study mitochondrial health across stages and shows preserved mitochondrial function and treatment responses.

Fxr1 regulates sleep and synaptic homeostasis

This study shows Fxr1 is downregulated during synaptic scaling and sleep deprivation, linking it to homeostatic plasticity and sleep regulation.

CRISPR/Cas9 mediated intersectional knockout of GSK3β in D2 receptor expressing mPFC neurons reveals contributions to emotional regulation

This study uses CRISPR/Cas9 to knockout GSK3β in D2 receptor expressing mPFC neurons, revealing its role in emotional regulation and behavior.

A non-linear relation between levels of adult hippocampal neurogenesis and expression of the immature neuron marker doublecortin

The paper shows that doublecortin (DCX) expression does not linearly correlate with adult hippocampal neurogenesis (AHN) in various models, highlighting the need for caution in using DCX as a proxy for AHN.

Robust Production of Uniform Human Cerebral Organoids from Pluripotent Stem Cells

This study develops a robust method to produce uniform human cerebral organoids with consistent morphology and cell type composition, achieving an 80% success rate.

High sensitivity mapping of cortical dopamine D2 receptor expressing neurons

The paper identifies and maps D2 receptor expressing neurons in the adult mouse cortex using multimodal techniques, revealing previously uncharacterized clusters and heterogeneity in receptor expression.