Author

Jooheon H. Shin

Lieber Institute for Brain Development

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Genomics· 3 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Assay:whole-genome sequencing· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

Andrew E. JaffeiD· 4 shared Daniel R. WeinbergeriD· 4 shared Richard E. StraubiD· 4 shared Alexander Eckehart UrbaniD· 3 shared Alexej S. AbyzoviD· 3 shared Alissa M. D’GamaiD· 3 shared Alon GaloriD· 3 shared Andrew J. ChessiD· 3 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersGenomics

Andrew E. JaffeORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

DeepMosaic: Control-independent mosaic single nucleotide variant detection using deep convolutional neural networks

Xiaoxu Yang, Xin Xu, Martin W. Breuss, Danny Antaki, Laurel Ball, Changuk Chung, Jiawei Shen, Chen Li, Renee D. George, Yifan Wang, Taejeong Bae, Yuhe Cheng, Alexej S. Abyzov, Liping Wei, Ludmil B. Alexandrov, , Sarah B. Emery

DeepMosaic detects mosaic single nucleotide variants without control samples using deep convolutional neural networks, achieving high accuracy and uncovering many variants missed by existing methods.

Nature Biotechnology · Jan 2, 2023Peer-reviewedGenomics

Somatic mosaicism in the mature brain reveals clonal cellular distributions during cortical development

Martin W. Breuss, Xiaoxu Yang, Johannes C. M. Schlachetzki, Danny Antaki, Addison J. Lana, Xin Xu, Changuk Chung, Guoliang Chai, Valentina Stanley, Qiong Song, Traci Fang Newmeyer, An Nguyen, Sydney O’Brien, Marten A. Hoeksema, Beibei Cao, , Xiaowei Zhu

The paper evaluates brain somatic mosaicism in the adult human to identify rules governing cellular distribution during embryogenesis.

Nature · Apr 20, 2022Peer-reviewedGenomics

Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia

Xiaowei Zhu, Bo Zhou, Reenal Pattni, Kelly Gleason, Chunfeng Tan, Agnieszka Kalinowski, Steven A. Sloan, Anna-Sophie Fiston-Lavier, Jessica Mariani, Dmitri A. Petrov, Ben A. Barres, Laramie E. Duncan, Alexej S. Abyzov, Hannes S. Vogel, Brain Somatic Mosaicism Network, , Gary W. Mathern

The paper introduces a machine learning method to detect somatic L1 insertions in human brain tissue, revealing their widespread distribution in neurons and glia and potential role in neuropsychiatric diseases.

Nature Neuroscience · Jan 11, 2021Peer-reviewedGenomics

Regional heterogeneity in gene expression, regulation and coherence in hippocampus and dorsolateral prefrontal cortex across development and in schizophrenia

Leonardo Collado‐Torres, Emily E. Burke, Amy Peterson, Jooheon H. Shin, Richard E. Straub, Anandita Rajpurohit, Stephen Andrew Semick, William S. Ulrich, Amanda J. Price, Cristian Valencia, Ran Tao, Amy Deep‐Soboslay, Thomas M. Hyde, Joel E. Kleinman, Daniel R. Weinberger, Andrew E. Jaffe

The paper identifies regional differences in gene expression and regulation in hippocampus and dorsolateral prefrontal cortex across development and in schizophrenia using RNA-seq data from 900 samples.

Neuron · Jun 4, 2019Peer-reviewedNeuroscience