A molecular switch: Ro5-3335 drives hematopoietic stem cell division and clonality through distinct RUNX1 binding partners
Anne L. Robertson, Yue Lü, Avik Choudhuri, Daniel Fernández-Pérez, Alex Maya Pombo, Caroline Kubaczka, Samuel J. Wattrus, Kyle D. Drake, Joseph Mandelbaum, Serine Avagyan, Song P. Yang, Rohan Bhattacharya, Rebecca J. Freeman, Victoria Chan, Megan C. Blair, , Leonard Ira Zon
This study identifies Ro5-3335 as a chemical that increases HSC clone number and clonal diversity by altering RUNX1 binding partners in zebrafish and mouse models.
bioRxiv · Jun 7, 2024 · PreprintCell Biology