Author

M. R. Sullivan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

M. G. Vander Heiden· 3 shared A. Muir· 2 shared C. A. Lewis· 2 shared A. De Cian· 1 shared A. Luengo· 1 shared A. M. Darnell· 1 shared A. N. Lau· 1 shared B. Grauman-Boss· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersCancer Biology

M. G. Vander Heiden

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cell envelope remodeling requires high concentrations of biotin during Mycobacterium abscessus model lung infection

M. R. Sullivan, K. McGowen, Q. Liu, C. Akusobi, D. C. Young, J. A. Mayfield, S. Raman, I. D. Wolf, D. B. Moody, C. C. Aldrich, A. Muir, E. J. Rubin

This study identifies biotin-dependent fatty acid remodeling as essential for Mycobacterium abscessus survival in the lung, suggesting biotin synthesis and fatty acid metabolism as therapeutic targets.

bioRxiv · Jul 20, 2022 · PreprintMicrobiology

Methionine synthase is essential for cancer cell proliferation in physiological folate environments

M. R. Sullivan, A. M. Darnell, M. F. Reilly, C. A. Lewis, M. G. Vander Heiden

This study shows methionine synthase is essential for cancer cell proliferation under physiological folate conditions but not in standard cell culture.

bioRxiv · Jun 12, 2020 · PreprintCancer Biology

Pancreatic Stellate Cells Secrete Deoxycytidine Conferring Resistance to Gemcitabine in PDAC

S. Dalin, M. R. Sullivan, E. Kreidl, A. N. Lau, B. Grauman-Boss, S. Fenoglio, A. Luengo, M. G. Vander Heiden, D. A. Lauffenburger, M. T. Hemann

This study shows that pancreatic stellate cells secrete deoxycytidine, which reduces the effectiveness of gemcitabine in PDAC by inhibiting its processing in cancer cells.

Cancer Research · Nov 15, 2019Peer-reviewedCancer Biology

Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells

E. B. Garcin, S. Gon, R. Prakash, M. R. Sullivan, G. J. Brunette, A. De Cian, J.-P. Concordet, C. Giovannangeli, W. G. Dirks, S. Eberth, K. A. Bernstein, M. Jasin, M. Modesti

This study investigates the roles of RAD51 paralogs in DNA repair across different human cell types, finding essential differences in their functions and identifying potential implications for cancer therapy.

bioRxiv · Apr 15, 2019Cell Biology

Quantification of microenvironmental metabolites in murine cancer models reveals determinants of tumor nutrient availability

M. R. Sullivan, L. V. Danai, C. A. Lewis, S. H. Chan, D. Y. Gui, T. Kunchok, E. A. Dennstedt, M. G. Vander Heiden, A. Muir

The paper quantifies microenvironmental metabolites in murine cancer models and identifies factors affecting tumor nutrient availability.

bioRxiv · Jan 3, 2019Cancer Biology