Author

K. P. Larsen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Approach:biophysical modeling· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

J. H. Hurley· 4 shared C. Ou· 2 shared S. Shukla· 2 shared A. B. Tong· 1 shared A. K. Cada· 1 shared A. L. Yokom· 1 shared C. J. Bustamante· 1 shared D. A. Petito· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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4 shared papersBiophysics

J. H. Hurley

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Author profile →

5 papers

Recent·Most cited

Mechanism and cellular function of direct membrane binding by the ESCRT and ERES-associated Ca2+-sensor ALG-2

S. Shukla, W. Chen, S. Rao, S. Yang, C. Ou, K. P. Larsen, G. Hummer, P. I. Hanson, J. H. Hurley

This study investigates how ALG-2 binds membranes and proteins in a Ca2+-dependent manner, revealing its role in membrane repair and ERES function.

bioRxiv · Oct 17, 2023 · PreprintBiophysics

A Flat Protein Complex Shapes Rough ER Membrane Sheets

E. M. Sawyer, L. E. Jensen, J. B. Meehl, K. P. Larsen, D. A. Petito, J. H. Hurley, G. K. Voeltz

The paper identifies Sigma-1 receptor as a factor shaping rough ER sheets through proteomics and imaging, showing its role in membrane flattening.

bioRxiv · Oct 6, 2023 · PreprintCell Biology

In vitro reconstitution of calcium-dependent recruitment of the human ESCRT machinery in lysosomal membrane repair

S. Shukla, K. P. Larsen, C. Ou, K. Rose, J. H. Hurley

This study reconstitutes the Ca2+-dependent recruitment of the human ESCRT machinery to lysosomal membranes in vitro, identifying ALG-2 as a key mediator of this process.

bioRxiv · Mar 30, 2022Cell Biology

Friction-driven membrane scission by the human ESCRT-III proteins CHMP1B and IST1

A. K. Cada, M. Remec Pavlin, J. P. Castillo, A. B. Tong, K. P. Larsen, X. Ren, A. L. Yokom, F.-C. Tsai, J. Shiah, P. Bassereau, C. J. Bustamante, J. H. Hurley

This study shows that CHMP1B and IST1 can sever membranes through a friction-driven mechanism, requiring constriction and extensional force, but not VPS4 or spastin.

bioRxiv · Feb 3, 2022 · PreprintBiophysics

De novo computational RNA modeling into cryoEM maps of large ribonucleoprotein complexes

K. Kappel, S. Liu, K. P. Larsen, G. Skiniotis, E. V. Puglisi, J. D. Puglisi, Z. H. Zhou, R. Zhao, R. Das

This paper introduces DRRAFTER, a method to model RNA-protein complexes from cryoEM maps, showing it can build accurate RNA coordinates in real-world scenarios.

bioRxiv · May 30, 2018Biophysics