K. Plath

Loss of cell junctional components and matrix alterations drive cell desquamation and fibrotic changes in Idiopathic Pulmonary Fibrosis

The study identifies loss of cell junctions and matrix dysregulation as drivers of epithelial desquamation and fibrosis in IPF distal bronchioles.

Linking single-cell transcriptomes with secretion using secretion-encoded single-cell sequencing (SEC-seq)

SEC-seq links single-cell transcriptomes with secretion levels by isolating cells and secretions in Nanovials, enabling analysis of secretory phenotypes and their genetic drivers.

Optimization of RNA Pepper sensors for the detection of arbitrary RNA targets

This paper develops and optimizes Pepper RNA sensors for detecting arbitrary RNA targets with high brightness and sensitivity.

Secretion encoded single-cell sequencing (SEC-seq) uncovers gene expression signatures associated with high VEGF-A secretion in mesenchymal stromal cells

SEC-seq links cell secretions to transcriptomes, revealing VEGF-A secretion heterogeneity and a unique gene signature in MSCs with high secretion.

Xist-seeded nucleation sites form local concentration gradients of silencing proteins to inactivate the X-chromosome

This study identifies Xist-seeded nucleation sites that create local concentration gradients of silencing proteins, leading to X-chromosome inactivation through macromolecular crowding.

Direct exposure to SARS-CoV-2 and cigarette smoke increases infection severity and alters the stemcell-derived airway repair response

This study shows that cigarette smoke exposure increases SARS-CoV-2 infection severity in airway cultures by reducing interferon response and ABSC proliferation.

A molecular atlas of proximal airway identifies subsets of known airway cell types revealing details of the unique molecular pathogenesis of Cystic Fibrosis

The paper uses single-cell transcriptomics to analyze proximal airway epithelium in CF and healthy donors, identifying molecular changes linked to CF pathogenesis.