Author

G. Georgiou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Research Focus:cell type annotation· 6 Approach:experimental assay· 6 Assay:proteomics· 5 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Approach:deep learning· 2 Research Focus:differential expression· 2

Frequent Co-Authors

G. C. Ippolito· 4 shared J. Lee· 3 shared W. N. Voss· 3 shared A. P. Horton· 2 shared A. Watanabe· 2 shared J. J. Lavinder· 2 shared J. R. McDaniel· 2 shared J. S. McLellan· 2 shared

Activity by Year

2017-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersImmunology

G. C. Ippolito

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Hybrid immunity to SARS-CoV-2 arises from serological recall of IgG antibodies distinctly imprinted by infection or vaccination

W. N. Voss, M. A. Mallory, P. O. Byrne, J. M. Marchioni, S. A. Knudson, J. M. Powers, S. R. Leist, B. Dadonaite, D. R. Townsend, J. Kain, Y. Huang, E. Satterwhite, I. N. Castillo, M. Mattocks, C. Paresi, , G. C. Ippolito

This study compares IgG antibody responses from SARS-CoV-2 infection, vaccination, and hybrid immunity, finding that hybrid immunity retains the imprint of the initial exposure and enhances antibody breadth and affinity.

Cell Reports Medicine · Aug 1, 2024Peer-reviewedImmunology

Mutability and hypermutation antagonize immunoglobulin codon optimality

J. J. McGrath, J. Park, C. A. Troxell, J. C. Chervin, L. Li, J. R. Kent, S. Changrob, Y. Fu, M. Huang, N.-Y. Zheng, G. D. Wilbanks, S. A. Nelson, J. Sun, G. Inghirami, M. L. L. Madariaga, , P. C. Wilson

The paper examines how immunoglobulin codon optimality interacts with mutability and hypermutation in antibody evolution, finding that codon deoptimization correlates with expression loss and is constrained by selective pressures.

bioRxiv · Mar 13, 2024Immunology

Infant antibody repertoires during the first two years of influenza vaccination

M. Kuraoka, N. C. Curtis, A. Watanabe, H. Tanno, S. Shin, K. Ye, E. Macdonald, O. Lavidor, S. Kong, T. Von Holle, I. W. Windsor, G. C. Ippolito, G. Georgiou, E. B. Walter, G. H. Kelsoe, , J. Lee

This paper studies how influenza vaccination in infants shapes their antibody responses, finding that vaccination can lead to immune imprinting similar to infection, with shifts in B-cell specificity and adult-like antibody repertoires after the second year.

bioRxiv · Sep 13, 2022Immunology

A prevalent focused human antibody response to the influenza hemagglutinin head interface

K. R. McCarthy, J. Lee, A. Watanabe, M. Kuraoka, L. R. Robinson-McCarthy, G. Georgiou, G. Kelsoe, S. Harrison

The paper identifies a focused, protective antibody response targeting a conserved region at the influenza hemagglutinin head interface, showing cross-serotype binding and potential for durable immunity.

bioRxiv · Dec 28, 2020Immunology

Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes in COVID-19 convalescent plasma

W. N. Voss, Y. J. Hou, N. V. Johnson, J. E. Kim, G. Delidakis, A. P. Horton, F. Bartzoka, C. J. Paresi, Y. Tanno, S. A. Abbasi, W. Pickens, K. George, D. R. Boutz, D. M. Towers, J. R. McDaniel, , G. C. Ippolito

The paper identifies prevalent, protective, and convergent IgG antibodies targeting non-RBD epitopes of SARS-CoV-2 spike protein in convalescent plasma.

bioRxiv · Dec 20, 2020Immunology

Comprehensive and Integrated Genomic Characterization of Human Immunome in Cancer

Y. Li, T. Triplett, B. Burgman, M. Sun, D. J. McGrail, D. Qi, S. Shukla, E. Wu, C. J. Wu, A. Capasso, S. G. Eckhardt, G. Georgiou, B. Li, N. Sahni, S. S. Yi

This study develops a network-based immunogenomics model to identify mutations affecting immune responses in cancer and suggests potential immunomodulatory drug candidates.

bioRxiv · Jun 2, 2020 · PreprintImmunology

Induction of pancreatic tumor-selective ferroptosis through modulation of cystine import

M. A. Badgley, D. Kremer, H. C. Maurer, K. E. DelGiorno, H.-J. Lee, V. Purohit, I. Sagalovskiy, A. Ma, J. Kapillian, C. E. M. Firl, A. R. Decker, S. A. Sastra, C. F. Palermo, L. R. Andrade, P. Sajjakulnukit, , K. P. Olive

The paper shows that targeting cystine import induces ferroptosis in pancreatic tumors, leading to tumor regression and improved survival in a mouse model.

bioRxiv · Nov 1, 2019 · PreprintCancer Biology

Identification of Tumor-Reactive B Cells and Systemic IgG in Breast Cancer Based on Clonal Frequency in the Sentinel Lymph Node

J. R. McDaniel, S. C. Pero, W. N. Voss, G. S. Shukla, Y. Sun, S. Schaetzle, C.-H. Lee, A. P. Horton, S. Harlow, J. Gollihar, J. W. Ellefson, C. C. Krag, Y. Tanno, N. Sidiropoulos, G. Georgiou, , D. N. Krag

The paper identifies tumor-reactive B cells in sentinel lymph nodes and links them to systemic IgG antibodies in breast cancer patients using high-throughput sequencing and immunoproteomics.

bioRxiv · Nov 1, 2017Immunology

Regulatory remodeling in the allo-tetraploid frog Xenopus laevis

D. M. Elurbe, S. S. Paranjpe, G. Georgiou, I. van Kruijsbergen, O. Bogdanovic, R. Gibeaux, R. Heald, R. Lister, M. A. Huynen, S. J. van Heeringen, G. J. C. Veenstra

This study investigates the genomic and epigenomic consequences of whole genome duplication in Xenopus laevis, finding that subgenome degradation and regulatory element innovation are linked to repeats and non-allelic homologous recombination.

bioRxiv · Mar 24, 2017Evolutionary Biology