M. Kuraoka

A protective and broadly binding antibody class engages the influenza virus hemagglutinin head at its stem interface

This paper identifies a class of human antibodies that bind a conserved HA head-stem interface epitope, offering broad protection against influenza A serotypes in mice.

A class of antibodies that overcome a steric barrier to cross-group neutralization of influenza viruses

This paper identifies a class of antibodies that neutralize both H1 and H3 influenza viruses by overcoming a steric barrier at the HA RBS.

An epitope-enriched immunogen increases site targeting in germinal centers

This study shows that an epitope-enriched immunogen preferentially expands RBS-directed antibody responses compared to non-enriched immunogens.

Infant antibody repertoires during the first two years of influenza vaccination

This paper studies how influenza vaccination in infants shapes their antibody responses, finding that vaccination can lead to immune imprinting similar to infection, with shifts in B-cell specificity and adult-like antibody repertoires after the second year.

Recall of B cell memory depends on relative locations of prime and boost

The study shows that memory B cells form recall germinal centers more effectively when boosts are given at the same site as the initial immunization, leading to higher mutation levels and avidity in BCRs.

A prevalent focused human antibody response to the influenza hemagglutinin head interface

The paper identifies a focused, protective antibody response targeting a conserved region at the influenza hemagglutinin head interface, showing cross-serotype binding and potential for durable immunity.

Structure-guided molecular grafting of a complex broadly neutralizing viral epitope

This paper describes the engineering of immunogens that present a conserved viral epitope using avian influenza HAs, showing they are immunogenic and can enrich for RBS-directed antibodies.