L. Sun

This paper develops a high-throughput GlyExo-Capture technique to isolate fucosylated extracellular vesicles and identifies a 4-miRNA signature for hepatocellular carcinoma detection.

The paper identifies and validates genes involved in metabolite damage repair and preemption in the minimized Mycoplasma JCVI-Syn3A genome and extends its metabolic map.

This study identifies Nrf2/FAM134B-mediated ER-phagy as a protective mechanism against oxidative damage in intervertebral disc degeneration.

This study shows Maf1 regulates bone mass by modulating RNA polymerase III transcription, with both loss and gain of function leading to high bone mass, but through distinct mechanisms.

This study identifies the SUMM4 complex, which couples insulator function with DNA replication timing control in Drosophila by modulating replication fork progression through chromatin boundaries.

This study identifies H2B.8 as a histone variant that mediates chromatin condensation in flowering plant sperm through phase separation, enabling nuclear compaction without transcriptional inhibition.

This study compares the evolutionary adaptation of a minimal synthetic cell to its non-minimized counterpart, finding equivalent adaptation rates despite fitness loss from genome streamlining.

This study identifies CycK:CDK13 as a kinase complex that phosphorylates SERINC5 at S360, enhancing Nef-mediated downregulation and counteracting its antiviral activity.

This study investigates the conformation and dynamics of the denatured state ensemble (DSE) of a membrane protein in a native lipid bilayer, finding it is dynamic and partially expanded.

This study compares the immunogenicity of spike proteins from Alpha- and Beta-coronaviruses, finding that Beta-CoVs induce stronger neutralizing antibodies against RBD than Alpha-CoVs.

This study shows Zika virus uses extracellular vesicles to transmit infection by packaging viral components and evading immune responses.

This study identifies NEDD4 as an E3 ubiquitin ligase that ubiquitinates and destabilizes IGPR-1 via lysosomal degradation.

This study identifies N4BP1 as an inhibitor of NF-κB activation by interacting with NEMO, and shows that caspase 8 cleavage inactivates N4BP1 during TRIF-dependent signaling.

This paper identifies a mammalian-unique eIF4E2-GSK3β pathway that prevents senescence and protects against hypoxia by maintaining p53 phosphorylation.

This study identifies membrane composition changes as a key factor in E. coli persistence using genomic, transcriptomic, and lipidomic analyses of a high-persistence mutant.

This study investigates L-arabinose's antifeedant effects on cotton bollworm caterpillars, showing it deters feeding, suppresses gustatory responses, and inhibits sucrase activity.

The paper identifies mutations in picornaviruses that confer resistance to vapendavir, including both pocket and non-pocket mutations, and shows some mutations require drug presence for viral replication.

This paper introduces PrismNet, a deep learning model that uses in vivo RNA structures to predict protein-RNA interactions and identifies disease-associated mutations affecting these interactions.

The paper shows that IMD/Relish suppresses perilipin1, leading to lipid droplet enlargement that reduces ROS stress during bacterial infection in Drosophila.

The paper investigates how CBL mutations drive oncogenesis by enhancing LYN kinase activity and PI3K/AKT signaling, suggesting LYN inhibition as a therapeutic strategy.

The paper identifies a 382-nt deletion in SARS-CoV-2 ORF8 from Singapore patients, which enhances N gene transcription and may contribute to viral attenuation.

This study shows eIF3 interacts with 80S ribosomes to enhance early translation elongation of mRNAs involved in mitochondrial and membrane functions, critical for muscle health.

This study identifies a mutational cascade triggered by chromosome bridge formation that leads to chromothripsis and contributes to cancer genome complexity and sub-clonal heterogeneity.

This paper studies how bacterial predator-prey interactions drive genome evolution and select for virulence-associated prey defenses.

This study shows stochastic gene expression affects the selection of antibiotic resistance mutations, with regulatory and structural mutations providing different resistance mechanisms.

The paper introduces VHUT-cryo-FIB, a workflow for preparing frozen-hydrated tissue lamella for cryo-ET, and demonstrates its effectiveness using rat and spinach samples.

The paper identifies a crosstalk mechanism between brassinosteroid and auxin signaling in Arabidopsis thaliana, showing BR signaling regulates nuclear auxin levels via PILS protein dynamics.

The paper identifies genome-wide SNPs and InDels in four Actinidia arguta genotypes using whole-genome re-sequencing and links them to functional genes involved in stress responses and hormone signaling.

This study identifies ALI-1 as a candidate gene for the B1 locus, showing its role in regulating awn length and grain weight in wheat through cytokinin suppression.

This paper introduces a Tmem119-tdTomato reporter mouse model to specifically study microglia in the CNS, showing tdTomato+ cells are microglia-specific and detectable in health and disease.