L. Yu

This study shows rottlerin reduces DSS-induced colitis in mice by enhancing intestinal barrier function through the Epac-2/Rap-1 signaling pathway.

This study shows UFMylation regulates translation and cell cycle progression by controlling eIF4F complex assembly and ribosome recruitment, independent of stress response pathways.

The paper uses single-cell RNA-seq data to identify subclonal compositions in TNBC and links them to survival outcomes and immune microenvironment diversity.

This study evaluates a novel three-dimensional grid intrauterine device (3-DGIUD) in rhesus macaques, finding it effective for contraception without significant impact on endometrial steroid receptors and PAX2 expression.

This study identifies the DNA specificity and structural basis of BRG1's composite domain using SELEX-seq, NMR, and modeling, showing how cancer mutations alter DNA binding.

The paper investigates somatic genetic variation in modular species, finding that clonal growth leads to genetically differentiated modules with varying levels of selection.

The paper develops an optimality model to predict leaf nitrogen changes under variable CO2 and nutrient conditions, showing it better captures observed patterns than existing models.

This study investigates the molecular mechanism of PA transfer by Ups1/Mdm35 using crystal structures, molecular dynamics simulations, and biophysical assays, revealing conformational changes and regulatory factors.

The paper shows Cyclin B1-CDK1 binds MAD1 at the nuclear pore, coordinating NPC disassembly with kinetochore assembly to maintain chromosomal stability.

The paper characterizes the midbody interactome, revealing PP1 phosphatases regulate microtubule dynamics and centralspindlin complex function during cytokinesis.

This study tracks the development of a potent ZIKV-specific antibody in a convalescent human, revealing limited somatic hypermutation and high germline identity.

The paper shows C1orf109L promotes R-loop accumulation, causing DNA damage and cell cycle arrest, which inhibits cell growth and may be a target for cancer therapy.

This study investigates transcriptomic responses of Symbiodinium kawagutii to thermal stress, phosphate deprivation, and glycerol-3-phosphate replacement, identifying core genes and differentially expressed genes across conditions.

This paper introduces E2~dID, a method to identify substrates modified by ubiquitin and ubiquitin-like molecules using E2-thioester conjugates, validated in human and yeast systems.

This paper introduces a tumor-specific causal inference framework to identify causative somatic genome alterations and their impact on molecular phenotypes in individual tumors.

The paper creates a multi-omic atlas of the human frontal cortex using data from aging and Alzheimer's studies, providing insights into brain biology and disease mechanisms.

This study identifies phosphoregulation networks during Plasmodium gamete formation using high-resolution phosphoproteomics.