Author

A. Yisimayi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Immunology· 15

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Research Focus:host-pathogen & immune response· 14 Approach:experimental assay· 12 Assay:proteomics· 10 Organism:human· 8 Organism:virus· 4 Organism:mouse· 2 Approach:statistical model· 2 Approach:deep learning· 1

Frequent Co-Authors

F. Shao· 14 shared Y. Wang· 14 shared F. Jian· 13 shared J. Wang· 13 shared R. Jin· 13 shared W. Song· 13 shared P. Wang· 12 shared S. Yang· 11 shared

Activity by Year

2021-2024 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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14 shared papersImmunology

F. Shao

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15 papers

Recent·Most cited

Global variation in prior exposure shapes antibody neutralization profiles of SARS-CoV-2 variants up to BA.2.86

S. Turner, G. Amirthalingam, D. Bailey, D. H. Barouch, K. R. Bewley, K. Brown, Y. R. Cao, Y.-W. Chan, S. Charlton, DOVE consortium, N. S. Coombes, B. Hallis, D. D. Ho, F. Jian, N. Lasrado, , D. J. Smith

The paper analyzes antibody neutralization data from multiple countries to assess how prior exposure to SARS-CoV-2 variants affects neutralization profiles of BA.2.86 and its descendants.

bioRxiv · Mar 27, 2024 · PreprintImmunology

Antigenicity assessment of SARS-CoV-2 saltation variant BA.2.87.1

S. Yang, Y. Yu, F. Jian, A. Yisimayi, W. Song, J. Liu, P. Wang, Y. Xu, J. Wang, X. Niu, L. Yu, Y. Wang, F. Shao, R. Jin, Y. Wang, Y. Cao

This study assesses the antigenic properties and immune evasion of the SARS-CoV-2 variant BA.2.87.1, finding it less resistant to neutralizing antibodies than JN.1 but with compensatory deletions in the NTD.

bioRxiv · Mar 7, 2024Immunology

Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting

A. Yisimayi, W. Song, J. Wang, F. Jian, Y. Yu, X. Chen, Y. Xu, S. Yang, X. Niu, T. Xiao, J. Wang, L. Zhao, H. Sun, R. An, N. Zhang, , Y. Cao

This study shows repeated Omicron exposures reduce immune imprinting from wildtype vaccines, leading to higher neutralizing antibodies against XBB variants.

Nature · Nov 22, 2023Peer-reviewedImmunology

Fast evolution of SARS-CoV-2 BA.2.86 to JN.1 under heavy immune pressure

S. Yang, Y. Yu, Y. Xu, F. Jian, W. Song, A. Yisimayi, P. Wang, J. Wang, J. Liu, L. Yu, X. Niu, J. Wang, Y. Wang, F. Shao, R. Jin, , Y. Cao

The paper shows JN.1 outcompetes BA.2.86 and other variants by evading antibodies more effectively, despite reduced ACE2 binding.

bioRxiv · Nov 13, 2023Immunology

Antigenicity and infectivity characterization of SARS-CoV-2 BA.2.86

S. Yang, Y. Yu, F. Jian, W. Song, A. Yisimayi, X. Chen, Y. Xu, P. Wang, L. Yu, J. Wang, X. Niu, J. Wang, T. Xiao, R. An, Y. Wang, , Y. R. Cao

This study characterizes the antigenic properties and infectivity of the SARS-CoV-2 BA.2.86 variant, finding it evades immune responses but has reduced infectivity compared to previous variants.

bioRxiv · Sep 1, 2023 · PreprintImmunology

Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455-456 synergistically enhances antibody evasion and ACE2 binding

F. Jian, L. Feng, S. Yang, Y. Yu, L. Wang, W. Song, A. Yisimayi, X. Chen, Y. Xu, P. Wang, L. Yu, J. Wang, L. Liu, X. Niu, J. Wang, , Y. R. Cao

This study shows that convergent evolution of SARS-CoV-2 XBB lineages at RBD positions 455-456 synergistically enhances antibody evasion and ACE2 binding through epistatic interactions.

bioRxiv · Aug 30, 2023Immunology

Protective effect of plasma neutralization from prior SARS-CoV-2 Omicron infection against BA.5 subvariant symptomatic reinfection

X. Chen, Y. Xu, Y. Xie, W. Song, Y. Hu, A. Yisimayi, F. Shao, L. Geng, Y. Wang, H. Gao, Y. Shi, S. Zhang, R. Jin, Z. Shen, Y. R. Cao

The paper assesses the protective effect of neutralizing antibodies from prior Omicron BA.5 infection against symptomatic reinfection with BA.5, BF.7, CH.1.1, and XBB.1.5 subvariants, finding a strong correlation between antibody titers and reduced reinfection risk.

bioRxiv · Feb 14, 2023Immunology

Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution

Y. Cao, F. Jian, J. Wang, Y. Yu, W. Song, A. Yisimayi, J. Wang, R. An, X. Chen, N. Zhang, Y. Wang, P. Wang, L. Zhao, H. Sun, L. Yu, , X. S. Xie

The paper shows that convergent evolution of Omicron variants evades antibodies from BA.5 infections while maintaining ACE2 binding, driven by immune imprinting.

bioRxiv · Sep 15, 2022Immunology

Further humoral immunity evasion of emerging SARS-CoV-2 BA.4 and BA.5 subvariants

F. Jian, Y. Yu, W. Song, A. Yisimayi, L. Yu, Y. Gao, N. Zhang, Y. Wang, F. Shao, X. Hao, Y. Xu, R. Jin, Y. Wang, X. S. Xie, Y. Cao

This study shows that BA.4.6, BA.4.7, and BA.5.9 subvariants with R346 mutations evade humoral immunity more effectively than BA.4/BA.5, reducing neutralization titers by 1.5-2.6-fold.

bioRxiv · Aug 9, 2022Immunology

Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents

Y. R. Cao, F. Jian, Z. Zhang, A. Yisimayi, X. Hao, L. Bao, F. Yuan, Y. Yu, S. Du, J. Wang, T. Xiao, W. Song, Y. Zhang, P. Liu, R. An, , X. S. Xie

The paper identifies a potent and broad sarbecovirus-neutralizing antibody cocktail, SA55+SA58, from SARS convalescents to combat Omicron variants and other fast-evolving viruses.

bioRxiv · Aug 3, 2022Immunology

Characterizations of enhanced infectivity and antibody evasion of Omicron BA.2.75

Y. Cao, W. Song, L. Wang, P. Liu, C. Yue, F. Jian, Y. Yu, A. Yisimayi, P. Wang, Y. Wang, Q. Zhu, J. Deng, W. Fu, L. Yu, N. Zhang, , X. Wang

This study characterizes the enhanced infectivity and antibody evasion properties of the SARS-CoV-2 Omicron subvariant BA.2.75 compared to BA.5 and other variants.

bioRxiv · Jul 18, 2022Immunology

BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection

Y. R. Cao, A. Yisimayi, F. Jian, W. Song, T. Xiao, L. Wang, S. Du, J. Wang, Q. Li, X. Chen, Y. Yu, P. Wang, Z. Zhang, P. Liu, R. An, , X. S. Xie

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

bioRxiv · Apr 30, 2022Immunology

Omicron BA.2 specifically evades broad sarbecovirus neutralizing antibodies

Y. Cao, A. Yisimayi, F. Jian, T. Xiao, W. Song, J. Wang, S. Du, Z. Zhang, P. Liu, X. Hao, Q. Li, X. Chen, L. Wang, P. Wang, R. An, , X. S. Xie

This study shows that BA.2 causes stronger antibody evasion than BA.1, particularly in SARS convalescents, and identifies key mutations responsible for this escape.

bioRxiv · Feb 7, 2022 · PreprintImmunology

Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

Y. R. Cao, J. Wang, F. Jian, T. Xiao, W. Song, A. Yisimayi, W. Huang, Q. Li, P. Wang, R. An, J. Wang, Y. Wang, X. Niu, S. Yang, H. Liang, , X. S. Xie

This study identifies how Omicron evades neutralizing antibodies by analyzing mutations and their effects on different epitope groups, showing over 85% of tested antibodies are escaped.

bioRxiv · Dec 7, 2021Immunology

Circular RNA Vaccines against SARS-CoV-2 and Emerging Variants

L. Qu, Z. Yi, Y. Shen, L. Lin, F. Chen, Y. Xu, Z. Wu, H. Tang, X. Zhang, F. Tian, C. Wang, X. Xiao, X. Dong, L. Guo, S. Lu, , W. Wei

This paper develops a circular RNA vaccine encoding SARS-CoV-2 Spike RBD, showing broad protection against multiple variants including Delta and Omicron.

bioRxiv · Mar 16, 2021Immunology