Xin Sun

The paper identifies mesothelial cell plasticity as a key determinant of regenerative versus degenerative lung repair by comparing pneumonectomy and chronic lung allograft dysfunction models.

The paper shows that the ARID1A-containing BAF complex is essential for lung development, proximal-distal axis specification, and cell fate acquisition during respiratory development.

This study identifies a non-canonical role of Myc in basal cells during influenza infection, showing its necessity for mucosal restoration and recruitment of CD8+ NKT cells.

The paper creates a high-resolution multimodal lung atlas using single-nucleus RNA and chromatin data from 11 healthy adults, identifying 70 cell populations and 332,846 chromatin regions.

This study identifies Msi2 as a key regulator in lung cancer initiation and progression, showing its dual role in sensitizing cells to transformation and driving tumor growth.

This study shows that MYRF is essential for mesothelial cell function in lung development and maturation, with its mutation causing congenital diaphragmatic hernia.

This paper presents a single-cell atlas of the mouse upper respiratory epithelium, identifying 17 cell types organized into three spatial compartments and revealing distinct transcriptional programs.

The paper constructs a single-cell reference atlas for human and mouse lung tissues to improve cell type annotation and data integration.

The paper identifies distinct subtypes of cardiac-innervating sympathetic neurons using viral tracing and single-cell RNA sequencing, revealing their unique physiological roles in stress responses.

The paper describes the LungMAP Portal Ecosystem, a centralized resource integrating multi-omics and imaging data across species to enable standardized analysis of lung biology and disease.

The paper uses single-cell transcriptomics to analyze liver development in mice, identifying cell types, metabolic zonation, and a transient macrophage population.

The paper identifies LONP1 and ALYREF as new candidate risk genes for congenital diaphragmatic hernia through de novo and ultra-rare variant analyses in proband-parent trios and population controls.

The paper uses single nucleus ATAC-seq and RNA-seq to show age-related changes in chromatin accessibility and gene expression linked to SARS-CoV-2 entry genes in human lung cells.

Vaping nicotine-containing e-cigarettes causes addiction-like behaviors and cardiopulmonary issues in rats, which are reduced by varenicline.