Quinoline-based compounds can inhibit diverse enzymes that act on DNA
Jujun Zhou, Qin Chen, Ren Ren, Jie Yang, Bigang Liu, John R. Horton, Caleb Chang, Chuxuan Li, Leora Maksoud, Yifei Yang, Dante Rotili, Abhinav K. Jain, Xing Zhang, Robert Blumenthal, Taiping Chen, , Xiaodong Cheng
This study identifies quinoline-based compounds that inhibit DNA methyltransferases and other DNA-targeting enzymes, with compound 11 inducing DNA damage response in cancer cells.
Cell chemical biology · Oct 21, 2024Peer-reviewedMolecular Biology