Author

Lorna Leon

University of British Columbia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Jana K. Gillies· 2 shared Megan K. LevingsiD· 2 shared Ali Murtaza· 1 shared Andrew Brown· 1 shared Avery J. LamiD· 1 shared Carla ZimmermaniD· 1 shared Charles LauiD· 1 shared Christine M. WardelliD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBioengineering

Jana K. Gillies

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Tunable differentiation of human CD4+ and CD8+ T cells from pluripotent stem cells

Ross D. Jones, Kevin Salim, Laura N Stankiewicz, John M. Edgar, Lorna Leon, Jana K. Gillies, Ali Murtaza, Lauren J. Durland, Divy Raval, Charles Lau, Thristan P. Taberna, Han Hsuan Hsu, Carla Zimmerman, Yale S. Michaels, Fabio M V Rossi, , Peter W. Zandstra

This study shows how to generate CD4+ T cells from pluripotent stem cells by controlling Notch and T cell receptor signaling, enabling clonally diverse and expandable cells that can differentiate into helper cell types.

Cell stem cell · Jan 1, 2026Peer-reviewedBioengineering

Fourth generation CAR Tregs with PDCD1-driven IL-10 have enhanced suppressive function

Dominic A. Boardman, Sonya Mangat, Jana K. Gillies, Lorna Leon, Vivian C. W. Fung, Manjurul Haque, Majid Mojibian, Torin Halvorson, Qing Bo Huang, Karoliina Tuomela, Christine M. Wardell, Andrew Brown, Avery J. Lam, Megan K. Levings

This study engineers CAR Tregs to secrete IL-10 via PDCD1-driven regulation, enhancing their suppressive function in vitro and in vivo.

Science Advances · Jun 13, 2025Peer-reviewedImmunology