Author

K. P. Campbell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

M. E. Anderson· 5 shared D. Venzke· 4 shared H. Okuma· 4 shared S. Joseph· 4 shared A. S. Walimbe· 3 shared J. M. Hord· 3 shared T. Yang· 3 shared T. Yonekawa· 3 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersBiochemistry

M. E. Anderson

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Author profile →

6 papers

Recent·Most cited

Identification of a short, single site matriglycan that maintains neuromuscular function in the mouse

T. Yang, I. Chandel, M. Gonzales, H. Okuma, S. J. Prouty, S. Zarei, S. Joseph, K. W. Garringer, S. Ocampo Landa, T. Yonekawa, A. S. Walimbe, D. P. Venzke, M. E. Anderson, J. M. Hord, K. P. Campbell

The paper identifies a shorter matriglycan on dystroglycan that maintains neuromuscular function in adult mice and protects skeletal muscle from damage.

bioRxiv · Dec 20, 2023 · PreprintBiochemistry

Dystroglycan N-terminal domain enables LARGE1 to extend matriglycan on α-dystroglycan and prevents muscular dystrophy

H. Okuma, J. M. Hord, I. Chandel, M. E. Anderson, D. Venzke, A. S. Walimbe, S. Joseph, Z. Gastel, Y. Hara, F. Saito, K. Matsumura, K. P. Campbell

This study shows that the N-terminal domain of dystroglycan is required for LARGE1 to extend matriglycan to its full length, preventing muscular dystrophy.

eLife · Feb 1, 2023Peer-reviewedBiochemistry

Structure and mechanism of LARGE1 matriglycan polymerase

S. Joseph, N. J. Schnicker, Z. Xu, T. Yang, J. Hopkins, M. Watkins, S. Chakravarthy, O. Davulcu, M. E. Anderson, D. Venzke, K. P. Campbell

The paper determines the cryo-EM structure of LARGE1 and shows it functions as a dimer to processively polymerize matriglycan on dystroglycan using alternating active sites.

bioRxiv · May 12, 2022Biochemistry

Large1 Gene Transfer in Older myd Mice with Severe Muscular Dystrophy Restores Muscle Function and Greatly Improves Survival

T. Yonekawa, A. J. Rauckhorst, S. Y. El-Hattab, M. A. Cuellar, D. Venzke, M. E. Anderson, H. Okuma, A. D. Pewa, E. B. Taylor, K. P. Campbell

This study shows that gene transfer using AAV2/9 CMV Large1 in older myd mice with severe muscular dystrophy restores muscle function and significantly improves survival.

bioRxiv · Oct 28, 2021Physiology

Cell Surface Glycan Engineering Reveals that Matriglycan Alone can Recapitulate Dystroglycan Binding and Function

M. O. Sheikh, C. J. Capicciotti, L. Liu, J. L. Praissman, D. G. Mead, M. A. Brindley, T. Willer, K. P. Campbell, K. W. Moremen, L. Wells, G.-J. Boons

This study shows matriglycan can independently bind Laminin, viral proteins, and antibodies, and block viral infection, suggesting it acts as a tunable receptor.

bioRxiv · May 10, 2021Biochemistry

POMK Regulates Dystroglycan Function via LARGE-mediated Elongation of Matriglycan

A. S. Walimbe, H. Okuma, S. Joseph, T. Yang, T. Yonekawa, J. M. Hord, D. Venzke, M. E. Anderson, S. Torelli, A. Manzur, M. Devereaux, M. Cuellar, S. Prouty, S. Ocampo Landa, L. Yu, , K. P. Campbell

This study shows that POMK phosphorylates core M3 to enable LARGE to elongate matriglycan on dystroglycan, preventing muscular dystrophy.

bioRxiv · Apr 6, 2020Biochemistry