A chemical strategy toward novel brain-penetrant EZH2 inhibitors
R. Liang, D. Tomita, Y. Sasaki, J. Ginn, M. Michino, D. J. Huggins, L. Baxt, S. Kargman, M. Shahid, K. Aso, M. Duggan, A. W. Stamford, E. DeStanchina, N. Liverton, P. T. Meinke, , R. E. Phillips
This paper identifies a chemical strategy to develop brain-penetrant EZH2 inhibitors and reports two novel compounds with improved properties.
bioRxiv · Jun 10, 2021Cancer Biology