Author

M. Duggan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2

Frequent Co-Authors

K. Aso· 2 shared M. A. Foley· 2 shared A. W. Stamford· 1 shared B. S. Coller· 1 shared C. Locuson· 1 shared D. J. Huggins· 1 shared D. Nesic· 1 shared D. Tomita· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

K. Aso

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2 papers

Recent·Most cited

A chemical strategy toward novel brain-penetrant EZH2 inhibitors

R. Liang, D. Tomita, Y. Sasaki, J. Ginn, M. Michino, D. J. Huggins, L. Baxt, S. Kargman, M. Shahid, K. Aso, M. Duggan, A. W. Stamford, E. DeStanchina, N. Liverton, P. T. Meinke, , R. E. Phillips

This paper identifies a chemical strategy to develop brain-penetrant EZH2 inhibitors and reports two novel compounds with improved properties.

bioRxiv · Jun 10, 2021Cancer Biology

Novel Pure αVβ3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations

J. Li, Y. Fukase, Y. Shang, W. Zou, J. Munoz-Felix, L. Buitrago, J. van Agthoven, Y. Zhang, R. Hara, Y. Tanaka, R. Okamoto, T. Yasui, T. Nakahata, T. Imaeda, K. Aso, , B. S. Coller

This paper designs and evaluates two small-molecule Vβ3 antagonists that inhibit cell adhesion and bone resorption without inducing receptor conformational changes or enhancing angiogenesis at low concentrations.

bioRxiv · May 24, 2019Pharmacology & Toxicology