Author

M. A. Matthay

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Sil· 2 shared C. R. Simoneau· 2 shared G. Ali· 2 shared H.-L. Ji· 2 shared L. Rodriguez· 2 shared M. Ott· 2 shared R. Zhao· 2 shared X. Fang· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

A. Sil

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

NF-κB inhibitor alpha has a cross-variant role during SARS-CoV-2 infection in ACE2-overexpressing human airway organoids

C. R. Simoneau, P.-Y. Chen, G. X. Xing, M. M. Khalid, N. L. Meyers, J. M. Hayashi, T. Y. Taha, K. E. Leon, T. Ashuach, K. A. Fontaine, L. Rodriguez, B. Joehnk, K. Walcott, S. Vasudevan, X. Fang, , M. Ott

The paper uses ACE2-overexpressing airway organoids to show NF-κB inhibitor alpha is upregulated during SARS-CoV-2 infection and its reduced function increases viral infection.

bioRxiv · Aug 2, 2022 · PreprintMicrobiology

Immediate myeloid depot for SARS-CoV-2 in the human lung

M. Magnen, R. You, A. A. Rao, R. T. Davis, L. Rodriguez, C. R. Simoneau, L. Hysenaj, K. H. Hu, The UCSF COMET Consortium, C. Love, P. G. Woodruff, D. J. Erle, C. M. Hendrickson, C. S. Calfee, M. A. Matthay, , M. R. Looney

The paper investigates early SARS-CoV-2 infection in human lung myeloid cells, finding rapid viral tropism, ACE2 dependence, and poor interferon induction, suggesting a myeloid depot for viral persistence.

bioRxiv · Apr 28, 2022Immunology

Fibrinolytic niche is requested for alveolar type 2 cell-mediated alveologenesis and injury repair

G. Ali, R. Zhao, M. Zhang, K. G. Jain, J. Chang, S. Komatsu, X. Fang, B. Zhou, J. Liang, D. Jiang, M. Ikebe, M. A. Matthay, H.-L. Ji

This study shows that the fibrinolytic niche regulates alveolar type 2 cell function and regeneration through the uPA-A6-CD44-ENaC cascade, with implications for lung injury repair.

bioRxiv · Mar 24, 2020 · PreprintCell Biology

Plasmin improves oedematous blood-gas barrier by cleaving epithelial sodium channels

R. Zhao, G. Ali, H.-G. Nie, Y. Chang, D. Bhattarai, X. Su, X. Zhao, M. A. Matthay, H.-L. Ji

This study shows plasmin cleaves ENaC channels at multiple sites, enhancing fluid clearance in lung injury models.

bioRxiv · Feb 9, 2020Pharmacology & Toxicology