Author

M. Akamatsu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 6 Approach:experimental assay· 4 Assay:imaging· 3 Approach:microscopy & imaging analysis· 3 Assay:fluorescence / live-cell microscopy· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

D. G. Drubin· 3 shared P. Rangamani· 3 shared R. Vasan· 3 shared D. Serwas· 2 shared J. Schoeneberg· 2 shared A. Diz-Munoz· 1 shared A. Grassart· 1 shared A. Moayed· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersCell Biology

D. G. Drubin

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Local Monomer Levels and Established Filaments Potentiate Non-Muscle Myosin 2 Assembly

M. A. Quintanilla, H. Patel, H. Wu, K. A. Sochacki, M. Akamatsu, J. D. Rotty, F. Korobova, J. E. Bear, J. W. Taraska, P. W. Oakes, J. R. Beach

This study identifies biophysical mechanisms regulating non-muscle myosin 2 filament assembly using dynamic imaging and optogenetic tools, showing myosin monomer concentration and myosin:myosin interactions drive filament formation.

bioRxiv · Apr 26, 2023Cell Biology

Actin force generation in vesicle formation: mechanistic insights from cryo-electron tomography

D. Serwas, M. Akamatsu, A. Moayed, K. Vegesna, R. Vasan, J. M. Hill, J. Schoeneberg, K. M. Davies, P. Rangamani, D. G. Drubin

The paper uses cryo-electron tomography to study actin filament organization during clathrin-mediated endocytosis, revealing how actin dynamics generate pulling forces for vesicle formation.

bioRxiv · Jun 28, 2021Cell Biology

Load adaptation of endocytic actin networks

C. Kaplan, S. J. Kenny, S. Chen, J. Schoeneberg, E. Sitarska, A. Diz-Munoz, M. Akamatsu, K. Xu, D. G. Drubin

The paper investigates how actin networks adapt to membrane tension during clathrin-mediated endocytosis, finding that actin assembly increases under elevated load to maintain CME robustness.

bioRxiv · Apr 5, 2020 · PreprintCell Biology

A mechanical model reveals that non-axisymmetric buckling lowers the energy barrier associated with membrane neck constriction

R. Vasan, S. Rudraraju, M. Akamatsu, K. Garikipati, P. Rangamani

This study uses a mechanical model to show that non-axisymmetric buckling reduces the energy barrier for membrane neck constriction compared to symmetric necks.

bioRxiv · Nov 7, 2019Biophysics

Principles of self-organization and load adaptation by the actin cytoskeleton during clathrin-mediated endocytosis

M. Akamatsu, R. Vasan, D. Serwas, M. Ferrin, P. Rangamani, D. G. Drubin

The paper uses a multiscale model to show that actin networks enable clathrin-mediated endocytosis by self-organizing and adapting to membrane tension through Arp2/3 complexes and bent filaments.

bioRxiv · Jun 21, 2019Cell Biology

Differential scanning fluorimetric analysis of the amino-acid binding to taste receptor using a model receptor protein, the ligand-binding domain of fish T1r2a/T1r3

T. Yoshida, N. Yasui, Y. Kusakabe, C. Ito, M. Akamatsu, A. Yamashita

This study uses differential scanning fluorimetry to analyze amino-acid binding to the T1r2a/T1r3LBD model receptor, showing thermal stabilization and specificity for L-amino acids.

bioRxiv · Jun 13, 2019Biochemistry

Analysis Of Interphase Node Proteins In Fission Yeast By Quantitative And Super Resolution Fluorescence Microscopy

M. Akamatsu, Y. Lin, J. Bewersdorf, T. D. Pollard

The paper uses microscopy techniques to study interphase nodes in fission yeast, finding they have defined sizes and protein compositions, with type 1 nodes disassembling during mitosis and type 2 nodes remaining intact.

bioRxiv · May 14, 2017Cell Biology

Nanoscale Manipulation Of Membrane Curvature For Probing Endocytosis In Live Cells

W. Zhao, L. Hanson, H.-Y. Lou, M. Akamatsu, P. Chowdary, F. Santoro, J. Marks, A. Grassart, D. Drubin, Y. Cui, B. Cui

This study uses nanostructured substrates to control membrane curvature in live cells and finds that CME proteins prefer positive curvature, while other proteins do not.

bioRxiv · Mar 30, 2017Cell Biology