A. Diz-Munoz

Membrane to cortex attachment determines different mechanical phenotypes in LGR5+ and LGR5- colorectal cancer cells

This study identifies mechanical phenotype differences between LGR5+ and LGR5- colorectal cancer cells, linking them to membrane to cortex attachment proteins and metastatic potential.

The membrane-actin linkers ezrin, radixin, and moesin are dispensable for macrophage migration and cortex mechanics.

This study shows that ezrin, radixin, and moesin are not required for macrophage migration or actin cortex mechanics, challenging their universal importance in these processes.

The distance between the plasma membrane and the actomyosin cortex acts as a nanogate to control cell surface mechanics

The paper shows that the distance between the plasma membrane and actomyosin cortex, controlled by MCA proteins, acts as a nanogate regulating actin nucleation and cell surface mechanics.

Pulsed stimulated Brillouin microscopy enables high-sensitivity mechanical imaging of live and fragile biological specimens

This paper introduces pulsed stimulated Brillouin microscopy to improve mechanical imaging of live biological specimens with reduced phototoxicity and enhanced signal-to-background ratio.

High-resolution line-scan Brillouin microscopy for live-imaging of mechanical properties during embryo development

This paper introduces a high-resolution line-scan Brillouin microscope for live-imaging mechanical properties during embryo development with reduced photo-toxicity.

A mechano-osmotic feedback couples cell volume to the rate of cell deformation

The paper shows that cell volume depends on the rate of deformation, proposing a mechano-osmotic coupling model involving actin cortex and ion fluxes.

Sensing their plasma membrane curvature allows migrating cells to circumvent obstacles

The paper identifies a curvature-sensing mechanism in immune-like cells that enables obstacle avoidance through actin and membrane dynamics.

Load adaptation of endocytic actin networks

The paper investigates how actin networks adapt to membrane tension during clathrin-mediated endocytosis, finding that actin assembly increases under elevated load to maintain CME robustness.

Cell confinement reveals a branched-actin independent circuit for neutrophil polarity

This study shows that neutrophils can maintain polarity and movement without branched actin networks when confined, revealing a bleb-based protrusion mechanism distinct from the conventional actin-based one.

Cell surface mechanics gate stem cell differentiation

This study shows that changes in cell surface mechanics control stem cell differentiation by regulating membrane-to-cortex attachment in mouse embryonic stem cells.

Imaging mechanical properties of sub-micron ECM in live zebrafish using Brillouin microscopy

This study uses Brillouin microscopy to measure the thickness and mechanical properties of the ECM in live zebrafish, finding it to be ~400nm thick.

In vivo function of the lipid raft protein Flotillin 1 during CD8+ T cell-mediated host surveillance

This study investigates the role of Flotillin 1 in CD8+ T cell migration and immune responses, finding minimal impact on cell behavior under physiological conditions.