K. Meade-White

SARS-CoV-2 Omicron BA.1 and BA.2 are attenuated in rhesus macaques as compared to Delta

This study compares disease severity and viral load in rhesus macaques infected with SARS-CoV-2 Delta, Omicron BA.1, and BA.2 variants, finding Omicron variants cause less severe disease with lower viral loads.

A monoclonal antibody targeting the Nipah virus fusion glycoprotein apex imparts protection from disease

This study identifies a monoclonal antibody, mAb92, that targets the Nipah virus fusion glycoprotein and provides complete protection in hamsters.

A replicon RNA vaccine induces durable protective immunity from SARS-CoV-2 in nonhuman primates after neutralizing antibodies have waned

This study shows a replicon RNA vaccine provides durable protection against SARS-CoV-2 in nonhuman primates even after neutralizing antibodies decline.

Molnupiravir (MK-4482) is efficacious against Omicron and other SARS-CoV-2 variants in the Syrian hamster COVID-19 model

MK-4482 inhibits replication of multiple SARS-CoV-2 variants of concern, including Omicron, in the Syrian hamster model.

Replicating RNA platform enables rapid response to the SARS-CoV-2 Omicron variant and elicits enhanced protection in naïve hamsters compared to ancestral vaccine

SARS-CoV2 variant-specific replicating RNA vaccines protect from disease and pathology and reduce viral shedding following challenge with heterologous SARS-CoV2 variants of concern

This study evaluates a replicating RNA vaccine against SARS-CoV-2 variants, showing protection from disease and reduced viral shedding after heterologous challenge.

UK B.1.1.7 variant exhibits increased respiratory replication and shedding in nonhuman primates

This study compares the respiratory replication and shedding of SARS-CoV-2 D614G and B.1.1.7 variants in African green monkeys, finding increased respiratory replication for B.1.1.7 but no disease enhancement.

Recovery from acute SARS-CoV-2 infection and development of anamnestic immune responses in T cell-depleted rhesus macaques

This study shows that T cell depletion in rhesus macaques does not cause severe SARS-CoV-2 disease but delays viral clearance, and T cells are not essential for immunological memory or protection against re-infection.

A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques

A single intranasal dose of ChAd-SARS-CoV-2-S vaccine protects against SARS-CoV-2 infection in rhesus macaques by inducing neutralizing antibodies and T cell responses.

Immunocompetent Mouse Model for Crimean-Congo Hemorrhagic Fever Virus

This paper develops an immunocompetent mouse model for CCHFV that replicates human disease severity, enabling better study of host-viral interactions.

Defining the Syrian hamster as a highly susceptible preclinical model for SARS-CoV-2 infection

The paper shows Syrian hamsters are highly susceptible to SARS-CoV-2, making them a suitable model for developing countermeasures against COVID-19.

Hydroxychloroquine Proves Ineffective in Hamsters and Macaques Infected with SARS-CoV-2

This study shows hydroxychloroquine does not reduce SARS-CoV-2 replication or improve clinical outcomes in hamsters or macaques.

ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques

This study shows that the ChAdOx1 nCoV-19 vaccine reduces SARS-CoV-2 viral load and prevents pneumonia in rhesus macaques without causing immune-enhanced disease.

Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2

This study shows remdesivir reduces SARS-CoV-2 viral load and lung damage in rhesus macaques when administered early in infection.

A single dose of ChAdOx1 MERS provides broad protective immunity against a variety of MERS-CoV strains

A single dose of ChAdOx1 MERS vaccine protects rhesus macaques and mice against MERS-CoV infection and multiple strains.

Respiratory disease and virus shedding in rhesus macaques inoculated with SARS-CoV-2

This study shows that SARS-CoV-2 causes respiratory disease in rhesus macaques with symptoms similar to human cases, including prolonged viral shedding.