Author

K. M. Braun

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 5 Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2

Frequent Co-Authors

T. C. Friedrich· 6 shared C. M. Crooks· 3 shared Y. Kawaoka· 3 shared A. K. Haj· 2 shared A. M. Weiler· 2 shared A. S. Jaeger· 2 shared D. H. O'Connor· 2 shared G. K. Moreno· 2 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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6 shared papersMicrobiology

T. C. Friedrich

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Avian H7N9 influenza viruses are evolutionarily constrained by stochastic processes during replication and transmission in mammals

K. M. Braun, L. A. Haddock, C. M. Crooks, G. L. Barry, J. Lalli, G. Neumann, T. Watanabe, M. Imai, S. Yamayoshi, M. Ito, Y. Kawaoka, T. C. Friedrich

This study shows that H7N9 avian influenza viruses face strong evolutionary constraints during mammalian transmission, making human adaptation unlikely without rare, stochastic events.

bioRxiv · Apr 12, 2022Microbiology

Influenza A virus undergoes compartmentalized replication in vivo dominated by stochastic bottlenecks

K. A. Amato, L. A. Haddock, K. M. Braun, V. Meliopoulos, B. Livingston, R. Honce, G. A. Schaack, E. Boehm, C. A. Higgins, G. L. Barry, K. Koelle, S. Schultz-Cherry, T. C. Friedrich, A. Mehle

This study tracks influenza A virus diversity in ferrets, showing compartmentalized replication and stochastic bottlenecks shaping genetic diversity within lung lobes.

bioRxiv · Sep 28, 2021Microbiology

Prior dengue immunity enhances Zika virus infection of the maternal-fetal interface in rhesus macaques

C. M. Crooks, A. M. Weiler, S. L. Rybarczyk, M. I. Bliss, A. S. Jaeger, M. E. Murphy, H. A. Simmons, A. Mejia, M. K. Fritsch, J. M. Hayes, J. C. Eickhoff, A. M. Mitzey, E. Razo, K. M. Braun, E. A. Brown, , M. T. Aliota

This study shows that prior dengue virus immunity enhances Zika virus infection at the maternal-fetal interface in rhesus macaques but does not affect plasma replication or fetal outcomes.

bioRxiv · Jan 25, 2021 · PreprintMicrobiology

Transmission of SARS-CoV-2 in domestic cats imposes a narrow bottleneck

K. M. Braun, G. K. Moreno, P. J. Halfmann, E. B. Hodcroft, D. A. Baker, E. C. Boehm, A. M. Weiler, A. K. Haj, M. Hatta, S. Chiba, T. Maemura, Y. Kawaoka, K. Koelle, D. O'Connor, T. Friedrich

This study shows SARS-CoV-2 in cats has limited within-host genetic variation and a narrow transmission bottleneck, with a variant H655Y emerging and spreading across transmission pairs.

bioRxiv · Nov 16, 2020Microbiology

Rapid evolution of enhanced Zika virus virulence during direct vertebrate transmission chains

K. K. Riemersma, A. S. Jaeger, C. M. Crooks, K. M. Braun, J. Weger-Lucarelli, G. D. Ebel, T. C. Friedrich, M. T. Aliota

This study shows ZIKV adapts more rapidly to mice during direct transmission compared to mosquito or alternating host transmission, with a virulence-enhancing mutation emerging.

bioRxiv · Oct 23, 2020Microbiology

Characteristic and quantifiable COVID-19-like abnormalities in CT- and PET/CT-imaged lungs of SARS-CoV-2-infected crab-eating macaques (Macaca fascicularis)

C. L. Finch, I. Crozier, J. H. Lee, R. Byrum, T. K. Cooper, J. Liang, K. Sharer, J. Solomon, P. J. Sayre, G. Kocher, C. Bartos, N. M. Aiosa, M. Castro, P. A. Larson, R. Adams, , J. H. Kuhn

This study uses CT and PET/CT imaging to quantify SARS-CoV-2-induced lung abnormalities in crab-eating macaques, providing an objective endpoint for evaluating medical countermeasures.

bioRxiv · May 14, 2020 · PreprintMicrobiology

Limited SARS-CoV-2 diversity within hosts and following passage in cell culture

G. K. Moreno, K. M. Braun, P. J. Halfmann, T. M. Prall, K. K. Riemersma, A. K. Haj, J. Lalli, K. R. Florek, T. C. Friedrich, Y. Kawaoka, D. H. O'Connor

This study analyzes SARS-CoV-2 within-host diversity using metagenomic sequencing and finds low genetic variation with limited evidence of positive selection in clinical and cell culture samples.

bioRxiv · Apr 20, 2020 · PreprintMicrobiology