P. Khatri

Single-cell transcriptional landscape of temporal neutrophil response to burn wound in larval zebrafish

This study maps the temporal neutrophil response to burn wounds in larval zebrafish, identifying distinct subsets and their interactions, and links zebrafish myeloid signatures to human burn severity.

Systems immunology of transcriptional responses to viral infection identifies conserved antiviral pathways across macaques and humans

The paper identifies conserved antiviral pathways across macaques and humans using transcriptomic data from viral infections, showing shared and virus-specific responses that inform pandemic preparedness.

Disease Tolerance Acquired Through Repeated Plasmodium Infection Involves Epigenetic Reprogramming of Innate Immune Cells

The paper shows that repeated Plasmodium infection leads to epigenetic changes in innate immune cells, which suppress inflammation and confer long-term disease tolerance in Ugandan children.

Blood Transcriptional Correlates of BCG-Induced Protection Against Tuberculosis in Rhesus Macaques

The paper identifies blood transcriptional signatures from BCG-vaccinated rhesus macaques that correlate with protection against tuberculosis.

Rapid GPR183-mediated recruitment of eosinophils to the lung after Mycobacterium tuberculosis infection

This study shows that eosinophils migrate to the lungs early after Mycobacterium tuberculosis infection in mice and macaques, mediated by GPR183 and Ch25h, independent of CCR3.

Crosstalk of Histone Modifications in the Healthy Human Immune System

The paper analyzes histone post-translational modifications in human immune cells to uncover their interactions and functional implications.

Identification and targeting of a pan-genotypic influenza A virus RNA structure that mediates packaging and disease.

This paper identifies a conserved RNA structure in influenza A virus that mediates packaging and disease, showing that targeting it inhibits virus production and reduces disease severity.

Proximal and Distal Nephron-specific Adaptation to Furosemide

This study investigates how furosemide induces distinct adaptive responses in proximal and distal nephron segments, revealing mechanisms of diuretic resistance and tubular remodeling.

A novel stem cell type at the basal side of the subventricular zone maintains adult neurogenesis

The paper identifies a novel basal NSC population in the subventricular zone that contributes to adult neurogenesis, distinct from apical NSCs in molecular and functional properties.

Multiplexed imaging of human tuberculosis granulomas uncovers immunoregulatory features conserved across tissue and blood

This study uses multiplexed imaging and transcriptomics to identify immunosuppressive features in TB granulomas and blood, linking local and systemic immune responses.

Combined use of metagenomic sequencing and host response profiling for the diagnosis of suspected sepsis.

This study combines metagenomic sequencing and host response profiling to improve sepsis diagnosis by detecting pathogens and guiding clinical decisions.

A Unified Molecular Signature of Systemic Lupus Erythematosus Revealed by Integrated, Multi-Cohort Transcriptomic Analysis

This study identifies a 93-gene signature associated with SLE through multi-cohort transcriptomic analysis, showing its clinical relevance and independence from known SLE-related signatures.

CD38 contributes to human natural killer cell responses through a role in immune synapse formation

This study identifies CD38 as a key receptor in human NK cells that facilitates immune synapse formation, enhancing antiviral and antitumor responses.