Author

M. K. L. MacLeod

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

K. E. Hargrave· 2 shared A. Bravo-Blas· 1 shared A. Taggart· 1 shared A. Wickenhagen· 1 shared C. Boutell· 1 shared C. Loney· 1 shared D. M. Wall· 1 shared E. Hutchinson· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiochemistry

K. E. Hargrave

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Ovothiol is a redundant part of a complex thiol network in promastigote Leishmania mexicana

V. L. Bolton, L. L. Morrison, S. Khanra, R. Ritchie, K. E. Hargrave, R. J. S. Burchmore, M. K. L. MacLeod, M. P. Barrett

This paper shows that OvoA, an enzyme involved in ovothiol synthesis in Leishmania mexicana, is not essential for growth or infectivity but affects sensitivity to amphotericin B.

bioRxiv · Dec 8, 2023 · PreprintBiochemistry

Zoonotic avian influenza viruses evade human BTN3A3 restriction

R. M. Pinto, S. Bakshi, S. Lytras, M. K. Zakaria, S. Swingler, J. C. Worrell, V. Herder, M. Varjak, N. Cameron-Ruiz, M. Collados-Rodriguez, M. Varela, A. Wickenhagen, C. Loney, Y. Pei, J. Hughes, , M. Palmarini

This study identifies BTN3A3 as a human restriction factor that inhibits avian influenza viruses but not human IAVs, with resistance linked to specific NP mutations.

bioRxiv · Jun 14, 2022 · PreprintMicrobiology

Regulatory T cells control the dynamic and site-specific polarization of CD4 T cells following Salmonella infection

S. L. Clay, A. Bravo-Blas, D. M. Wall, M. K. L. MacLeod, S. W. F. Milling

This study shows that FoxP3+ regulatory T cells (Tregs) dynamically influence CD4 T cell polarization during Salmonella infection, shifting from suppressing Th17 to Th1 responses over time.

bioRxiv · May 25, 2020Immunology