T. P. Mathews

Ascorbate depletion increases quiescence and self-renewal potential in hematopoietic stem cells and multipotent progenitors

Stable isotope tracing in human plasma-like medium reveals metabolic and immune modulation of the glioblastoma microenvironment

This paper develops an in vitro method using human plasma-like medium to study glioma metabolism and immune interactions, revealing microenvironment-dependent metabolic features and immune responses.

Electron transport inhibition increases cellular dependence on purine transport and salvage

This study shows that ETC inhibition in cancer cells increases reliance on purine salvage and transport, revealing a metabolic vulnerability in tumors with low oxidative metabolism.

In-vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma

The paper identifies multiple glutamine metabolism pathways in ccRCC tumorgrafts and shows that targeting amidotransferase activity reduces tumor growth.

Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples

This paper develops an MS method to analyze all 16 aspartate and 32 glutamate isotopomers with high sensitivity, enabling pathway discrimination and metabolic heterogeneity studies in human tumors.

De Novo Pyrimidine Synthesis is a Targetable Vulnerability in IDH Mutant Glioma

This study identifies de novo pyrimidine synthesis as a therapeutic target in IDH mutant gliomas, showing that DHODH inhibitors are effective in preclinical models.

G6PD deficiency sensitizes metastasizing melanoma cells to oxidative stress and glutaminolysis

This study shows that G6PD deficiency in melanoma cells increases oxidative stress and glutaminolysis, reducing metastasis by making cells more vulnerable to metabolic disruption.

Cell-type specific requirement for pyruvate dehydrogenase in hematopoiesis and leukemia development.

The paper investigates whether metabolic requirements of leukemia cells reflect normal cell type metabolism, finding that PDH is required in T cell progenitors but not other hematopoietic cells.

Metabolomic profiling of rare cell populations isolated by flow cytometry from tissues

The paper develops a new metabolomic method for analyzing rare cell populations, detecting more metabolites in flow-sorted cells and revealing metabolic differences in HSCs and melanoma cells.