Author

S. Kanemura

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:chromatin & epigenetic regulation· 3 Organism:human· 3 Research Focus:protein folding & dynamics· 3 Assay:protein structure· 2 Assay:cryo-EM· 1 Assay:protein sequence· 1

Frequent Co-Authors

M. Okumura· 4 shared K. Inaba· 3 shared H. Kumeta· 2 shared M. Watabe· 2 shared T. Saio· 2 shared Y.-H. Lee· 2 shared C. Hirayama· 1 shared D. Ito· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersBiochemistry

M. Okumura

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5 papers

Recent·Most cited

Zinc finger domains bind low-complexity domain polymers

N. Iguchi, N. Isozumi, Y. Hattori, T. Imamura, M. So, H. Nanaura, T. Kiriyama, N. Eura, M. Yamaoka, M. Nakanishi, M. Mori, S. Ohki, H. Kumeta, H. Koga, M. Watabe, , E. Mori

This study shows zinc finger domains bind low-complexity domain polymers in a cross-β-dependent manner, suppressing polymer formation and preferentially recognizing polymeric LC domains.

bioRxiv · Oct 29, 2023 · PreprintBiochemistry

Dose-response relationship for the resistance of human insulin to degradation by insulin-degrading enzyme

M. Okumura, T. Kuramochi, Y. Lin, R. Furukawa, K. Mizutani, T. Yokoyama, M. Kim, M. H. Lim, H.-S. Yi, K. Arai, H. Yamaguchi, H. Hojo, M. Iwaoka, Y. Tanaka, S.-Y. Park, , Y.-H. Lee

The paper investigates how human insulin resistance to degradation by IDE varies with dose and identifies structural features of the insulin hexamer that influence degradation kinetics without zinc.

bioRxiv · Apr 8, 2023 · PreprintBiochemistry

A unique adhesive motif of protein disulfide isomerase P5 supports its function via dimerization

M. Okumura, S. Kanemura, M. Matsusaki, M. Kinoshita, T. Saio, D. Ito, C. Hirayama, H. Kumeta, M. Watabe, Y. Amagai, Y.-H. Lee, S. Akiyama, K. Inaba

This study identifies a unique adhesive motif in P5 that enables dimerization, which is essential for its structural stability and functional roles in ER quality control.

bioRxiv · Nov 17, 2020Biochemistry

Biochemical characterizations of ER-resident peroxidases, GPx7 and GPx8, reveal their distinct and regulated oxidative activities

S. Kanemura, E. F. Sofia, N. Hirai, M. Okumura, H. Kadokura, K. Inaba

This study characterizes GPx7 and GPx8, showing GPx7 efficiently oxidizes PDI via H2O2, while GPx8's role in PDI oxidation is less central.

bioRxiv · Mar 26, 2020 · PreprintBiochemistry

Protein secondary structure determines the temporal relationship between folding and disulfide formation

P. Robinson, S. Kanemura, X. Cao, N. Bulleid

This study investigates how protein secondary structure influences disulfide formation during folding, showing that disulfide-driven and folding-driven mechanisms depend on structural features.

bioRxiv · Sep 12, 2019Biochemistry