M. Tang

This study identifies N4BP1 as an inhibitor of NF-κB activation by interacting with NEMO, and shows that caspase 8 cleavage inactivates N4BP1 during TRIF-dependent signaling.

This study identifies TFR1, SAHH, and HV307 as potential biomarkers for colorectal cancer screening through proteomics analysis of pre-cancerous to cancerous tissues.

This study shows that influenza A virus pre-infection increases SARS-CoV-2 infectivity in multiple cell types and worsens lung damage in mice.

This study identifies enhancer subtypes in colorectal cancer through epigenomic analysis and proposes targeted therapeutic strategies based on these subtypes.

The paper shows that East Asian populations, particularly the Chinese Southern Han, have enhanced NK cell strength due to genetic admixture and natural selection of HLA class I alleles that interact with inhibitory KIR receptors.

The paper integrates multi-omic data from gliomas to show that epigenetic instability and transcriptional disruption are linked to tumor aggressiveness and environmental stress response.

This paper develops a high-accuracy multiplexed SARS-CoV-2 antibody assay using a nano-plasmonic platform, showing high specificity and sensitivity in serum and saliva samples.

This study uses single-cell RNA-sequencing to identify a transitional cell state in peripheral neuroblastic tumors associated with poor prognosis and therapeutic targets.

This study shows that anethole dithiolethione improves liver fatty acid metabolism in hamsters on high-fat diets by altering fatty acid profiles and regulating key metabolic pathways.

This study identifies six new Neodon species using systematic sampling and low coverage whole genome sequencing, revealing the Qinghai-Tibetan Plateau as the origin and highlighting climate change and geographic isolation as drivers of speciation.

This study identifies C17orf53 as a novel gene involved in inter-strand crosslink repair, showing its role in DNA replication and repair factor loading.

The paper identifies bivalent chromatin states and broad H3K4me3 domains associated with pro-metastatic drivers in melanoma using ChIP-sequencing data from tumor samples and cell lines.

The paper investigates how transcription factor networks modulate growth and defense in Arabidopsis, finding that their effects are conditional and not simply correlated.

The paper shows that Aux/IAA proteins regulate glucosinolate levels, which in turn affect drought tolerance in Arabidopsis by influencing stomatal regulation.

This study compares bacterial composition and functional differences between cancerous and noncancerous ovarian tissues using 16S rRNA sequencing and metagenomic predictions.

The paper examines how nucleotide binding and ATP hydrolysis affect the architecture of the Escherichia coli SMC complex MukBEF.

This study identifies KMT2D as a tumor suppressor in melanoma, showing its loss leads to metabolic reprogramming toward glycolysis and dependence on IGF signaling, suggesting therapeutic targeting of these pathways.

The paper shows synthetic and natural ligands can bind cooperatively to PPARγ, altering its structure and function through a 'ligand link' to the omega loop.

This study demonstrates that genome-skimming accurately quantifies mixed pollen samples, showing high repeatability and correlation between sequence reads and pollen proportions.

This study compares natural and experimental evolution of legume symbionts, finding similar patterns of purifying selection and adaptation through quorum-sensing systems.

The paper reports cancer-associated transcript fusions in 33 tumor types using TCGA data and provides a resource for accessing the results.