APOE genotype-dependent differences in human astrocytic energy metabolism
Vanessa Budny, Chantal Bodenmann, Kathrin J. Zürcher, Maik Krüger, Sherida M. de Leeuw, R. Weber, Ruslan Rust, Luca Ravotto, Iván Ruminot, L. Felipe Barros, Bruno Weber, Christian Tackenberg
This study investigates how different APOE genotypes affect human astrocytic energy metabolism, finding reduced ATP production in APOE4 astrocytes but increased mitochondrial respiration and glycolytic capacity.
Frontiers in Cellular Neuroscience · Sep 1, 2025Peer-reviewedNeuroscience