Daniela Noaín

Bidirectional restoration of sleep homeostasis in neurodegeneration via closed-loop auditory stimulation

This study shows that closed-loop auditory stimulation can restore sleep homeostasis in Alzheimer's and Parkinson's disease models by modulating cortical synchrony and arousal.

Sound-Enhanced Sleep Depth Reduces Traumatic Brain Injury Damage and Sequelae and Supports Microglial Response

mCLAS adaptively rescues disease-specific sleep and wake phenotypes in neurodegeneration

The paper demonstrates that mCLAS adaptively rescues disease-specific sleep and wake phenotypes in AD and PD mouse models.

Pharmacological enhancement of slow-wave activity improves cognition and reduces amyloidosis at an early stage in a mouse model of Alzheimer's disease

This study shows that enhancing slow-wave activity through sodium oxybate in early-stage Alzheimer's mice improves cognition and reduces amyloidosis, but not in older mice.

Novel murine closed-loop auditory stimulation paradigm elicits macrostructural sleep benefits in neurodegeneration

This study uses closed-loop auditory stimulation in mice to enhance slow-wave activity, improving sleep quality in Alzheimer's and Parkinson's disease models.

Spinal cord perfusion impairments in the M83 mouse model of Parkinson's disease

The paper uses multimodal imaging to assess spinal cord oxygenation and vascular changes in a PD mouse model, finding reduced oxygen saturation but no vascular impairment or atrophy.

Visualizing alpha-synuclein and iron deposition in M83 mouse model of Parkinson's disease in vivo

The paper visualizes alpha-synuclein inclusions and iron deposition in M83 mouse models of Parkinson's disease using in vivo imaging and ex vivo validation techniques.

Non-invasive imaging of tau-targeted probe uptake by whole brain multi-spectral optoacoustic tomography

This paper demonstrates non-invasive whole brain imaging of tau deposits using vMSOT and PBB5 probe in P301L mice, showing specific binding and retention in tau-laden regions.

Natural age-related sleep-wake alterations onset prematurely in the Tg2576 mouse model of Alzheimer disease

This study shows that Tg2576 mice exhibit early sleep-wake alterations resembling aged controls before plaque formation, suggesting premature sleep deterioration in AD models.

Closed-loop auditory stimulation method to modulate sleep slow waves and motor learning performance in rats

This paper demonstrates that phase-targeted closed-loop auditory stimulation in rats modulates sleep slow waves and improves motor learning performance.

Altered sleep intensity upon DBS to hypothalamic sleep-wake centers in rats

This study investigates the effects of high-frequency DBS on sleep-wake characteristics in rats, finding that it modulates sleep intensity without altering sleep proportions or stability.