Author

N. Castagna

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. M. De Marzo· 3 shared S. Yegnasubramanian· 3 shared A. Gupta· 2 shared A. M. Vaghasia· 2 shared A. Skaist· 2 shared J. Hicks· 2 shared J. Liu· 2 shared J. Meyers· 2 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

A. M. De Marzo

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Author profile →

3 papers

Recent·Most cited

Convergent alterations in the tumor microenvironment of MYC-driven human and murine prostate cancer

M. K. Graham, R. Wang, R. Chikarmane, B. Wodu, A. Vaghasia, A. Gupta, Q. Zheng, J. Hicks, P. Sysa-Shah, X. Pan, N. Castagna, J. Liu, J. Meyers, A. Skaist, Y. Zhang, , S. Yegnasubramanian

This study identifies MYC signaling activation as a common driver of tumor microenvironment alterations in human and murine prostate cancer through single-cell RNA-sequencing and comparative analysis.

bioRxiv · Sep 7, 2023Cancer Biology

Single-cell atlas of epithelial and stromal cell heterogeneity by lobe and strain in the mouse prostate

M. K. Graham, R. Chikarmane, R. Wang, A. M. Vaghasia, A. Gupta, Q. Zheng, B. P. Wodu, X. Pan, N. Castagna, J. Liu, J. Meyers, A. Skaist, S. J. Wheelan, B. W. Simons, C. Bieberich, , S. Yegnasubramanian

The paper constructs a single-cell atlas of mouse prostate cell types across strains and lobes, revealing strain- and lobe-specific transcriptomic differences in epithelial cells and strain-lobespecific fibroblast subtypes.

bioRxiv · Jan 31, 2022Cell Biology

PHENOTYPIC CHARACTERIZATION OF TWO NOVEL CELL LINE MODELS OF CASTRATION RESISTANT PROSTATE CANCER.

M. C. Haffner, A. Bhamidipati, H. K. Tsai, D. M. Esopi, A. M. Vaghasia, J.-Y. Low, R. A. Patel, G. Guner, M.-T. Pham, N. Castagna, J. Hicks, N. Wyhs, R. Aebersold, A. M. De Marzo, W. G. Nelson, , S. Yegnasubramanian

This study develops two novel castration-resistant prostate cancer cell lines and characterizes their transcriptomic and proteomic profiles to understand resistance mechanisms.

bioRxiv · Jul 4, 2021 · PreprintCancer Biology