B. W. Simons

Role of Adenosine Deaminase in Prostate Cancer Progression

This study identifies adenosine deaminase (ADA) as a driver of prostate cancer progression and metastasis through metabolomics and in vitro/in vivo experiments.

-Labeled PARP-1 PET Imaging of PSMA Targeted Alpha Particle Radiotherapy Response

This study uses [18F]-PARPZ PET imaging to assess alpha particle radiotherapy response in prostate cancer xenografts by tracking PARP-1 expression changes.

Single-cell atlas of epithelial and stromal cell heterogeneity by lobe and strain in the mouse prostate

The paper constructs a single-cell atlas of mouse prostate cell types across strains and lobes, revealing strain- and lobe-specific transcriptomic differences in epithelial cells and strain-lobespecific fibroblast subtypes.

MyoD-Cre driven alterations in K-Ras and p53 lead to a mouse model with histological and molecular characteristics of human rhabdomyosarcoma with direct translational applications

This paper develops a genetically engineered mouse model of rhabdomyosarcoma with molecular features similar to human RMS, providing pre-clinical tools for therapy evaluation.

PSMA Expression in the Hi-Myc Model; Extended Utility of a Representative Model of Prostate Adenocarcinoma for Biological Insight and as a Drug Discovery Tool

The paper shows that mPSMA is highly expressed in the Hi-Myc mouse model of prostate cancer, from early lesions to adenocarcinoma, supporting its use as a model for biological study and drug discovery.

First Whole-Body Three-Dimensional Tomographic Imaging of Alpha Particle Emitting Radium-223

This paper demonstrates SPECT imaging of alpha-emitting Radium-223 in phantoms and mice to assess its distribution and pharmacokinetics for dose optimization and therapeutic response.