Author

N. Hua

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Organism:multiple species· 1

Frequent Co-Authors

D. Zhou· 2 shared G. Zheng· 2 shared X. Liu· 2 shared X. Zhang· 2 shared A. Sobh· 1 shared C. Cheng· 1 shared C. Hann· 1 shared C. Ma· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

D. Zhou

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Evolutionary trajectory of TRPM2 channel activation by adenosine diphosphate ribose and calcium

C. Ma, Y. Luo, C. Zhang, C. Cheng, N. Hua, X. Liu, J. Wu, L. Qin, P. Yu, J. Luo, F. Yang, L.-H. Jiang, G. Zhang, W. Yang

The paper traces the evolutionary changes in TRPM2 channel activation mechanisms across species, identifying key stages in the transition from simple to complex ligand binding and calcium gating.

bioRxiv · Mar 18, 2024Evolutionary Biology

Co-targeting BCL-XL and MCL-1 with DT2216 and AZD8055 synergistically inhibits small-cell lung cancer growth without causing on-target toxicities in mice

S. KHAN, P. Kellish, N. Connis, D. Thummuri, J. Wiegand, P. Zhang, X. Zhang, V. Budamagunta, N. Hua, Y. Yang, U. De, L. Jin, W. Zhang, G. Zheng, R. Hromas, , D. Zhou

bioRxiv · Sep 12, 2022Cancer Biology

Piperlongumine (PL) conjugates induce targeted protein degradation

J. Pei, Y. Xiao, X. Liu, W. Hu, A. Sobh, Y. Yuan, S. Zhou, N. Hua, S. G. Mackintosh, X. Zhang, K. B. Basso, M. Kamat, Q. Yang, J. D. Licht, G. Zheng, , D. Lv

The paper identifies piperlongumine as a covalent E3 ligase recruiter that, when conjugated with CDK9 inhibitors, induces targeted protein degradation of CDK9 and EML4-ALK fusion oncoprotein.

bioRxiv · Jan 21, 2022Cancer Biology