N. Inagaki

Spontaneous cell morphogenesis via self-propelled actin filaments

The paper shows actin filaments move directionally via treadmilling, driving membrane protrusions and cell migration through physical mechanisms.

High-throughput screening for Cushing's disease: therapeutic potential of thiostrepton via cell cycle regulation

This study identifies thiostrepton as a potential therapy for Cushing's disease by inducing cell cycle arrest in PitNETs through mechanisms independent of FOXM1.

Novel Thyroid-Specific Autoantibodies in Patients with Immune-Related Adverse Events Involving the Thyroid Gland

This study identifies novel thyroid-specific autoantibodies in patients with immune-related adverse events involving the thyroid gland using immunoprecipitation and western blot analysis.

Mechanical Netrin-1-DCC Coupling Mediates Netrin-1-induced Axonal Haptotaxis

This study shows that netrin-1-induced axonal haptotaxis is mediated by mechanical coupling between netrin-1 and its receptor DCC, facilitated by shootin1a and actin flow.

Transcriptomic Landscape of Hyperthyroidism in Mice Overexpressing Thyroid Stimulating Hormone

This study analyzes the transcriptome of hyperthyroid mice overexpressing TSH, identifying novel genes and pathways associated with goiter development and thyroid hormone secretion.

Mechanical signaling through membrane tension induces somal translocation during neuronal migration

This study shows that mechanical signaling via membrane tension and mechanosensitive ion channels links leading process extension to somal translocation during neuronal migration.

Deciphering transcriptomic signatures explaining the phenotypic plasticity of non-heading lettuce genotypes under artificial light conditions

This study identifies genotype-environment interactions in lettuce under artificial light using transcriptome-based modeling, revealing key pathways and optimal genotype-light combinations for phenotypic plasticity.

Cell-surface protein YwfG of Lactococcus lactis binds to α-1,2-linked mannose

This study identifies YwfG as a cell-surface protein in Lactococcus lactis that binds α-1,2-linked mannose, revealing its role in interactions with yeast cells.

TRIAC disrupts cerebral thyroid hormone action via a negative feedback loop and heterogenous distribution among organs

This study shows TRIAC disrupts cerebral thyroid hormone action by reducing circulating TH levels and being poorly distributed to the brain, while compensating in peripheral tissues.

Cell Adhesion-Dependent Biphasic Axon Outgrowth Elucidated by Femtosecond Laser Impulse

This study uses femtosecond laser impulses to investigate how adhesion strength affects axon outgrowth, finding biphasic behavior due to the balance between traction force and adhesion strength.

Guided Axon Outgrowth of Neurons by Real-Time Femtosecond Laser Penetration on a 4 μm Thick Thin-Glass Sheet

This study uses a real-time femtosecond laser and microfluidic device to guide axon outgrowth by creating netrin-1 gradients, achieving 92% guided axon growth.

Three-dimensional analysis of β-cell proliferation by a novel mouse model

This study develops a novel mouse model to analyze β-cell proliferation using a fluorescent reporter system and 3D imaging.