Author

N. Spielmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Approach:benchmark study· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

H. Fuchs· 4 shared V. Gailus-Durner· 3 shared A. Sanz-Moreno· 2 shared B. Rathkolb· 2 shared D. Führer· 2 shared D. Geist· 2 shared G. S. Hönes· 2 shared I. Treise· 2 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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4 shared papersPhysiology

H. Fuchs

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Comparative phenotyping of mice reveals canonical and noncanonical physiological functions of TRα and TRβ

G. S. Hönes, D. Geist, C. Wenzek, P. T. Pfluger, T. D. Müller, O. V. Amarie, L. Becker, N. Dragano, L. Garrett, S. M. Hölter, B. Rathkolb, J. Rozman, N. Spielmann, I. Treise, E. Wolf, , L. C. Moeller

This study compares TRα and TRβ knockout mice with DNA-binding-deficient mutants to show noncanonical TR signaling contributes to physiological functions beyond canonical genomic pathways.

bioRxiv · Nov 26, 2023Physiology

Canonical and noncanonical contribution of thyroid hormone receptor isoforms alpha and beta to cardiac hypertrophy and heart rate in male mice

D. Geist, G. S. Hönes, S. C. Grund, J. Pape, D. Siemes, P. Spangenberg, E. Tolstik, S. Dörr, N. Spielmann, H. Fuchs, V. Gailus-Durner, M. Hrabe de Angelis, J. Mittag, D. R. Engel, D. Führer, , L. C. Moeller

This study shows that thyroid hormone-induced cardiac hypertrophy relies on noncanonical TR action, while heart rate regulation depends on canonical TR action, with TRβ compensating for TR absence.

bioRxiv · Nov 24, 2023Physiology

TRPS1 maintains luminal progenitors in the mammary gland by repressing SRF/MRTF activity

M. Tollot-Wegner, M. A. Jessen, K. Kim, A. Sanz-Moreno, N. Spielmann, V. Gailus-Durner, H. Fuchs, M. Hrabe de Angelis, B. von Eyss

This study shows TRPS1 maintains luminal progenitors in the mammary gland by repressing SRF/MRTF activity, linking it to mechanotransduction and breast cancer initiation.

bioRxiv · Nov 24, 2023Cell Biology

Deep Phenotyping and Lifetime Trajectories Reveal Limited Effects of Longevity Regulators on the Aging Process in C57BL/6J Mice

K. Xie, H. Fuchs, E. Scifo, D. Liu, A. Aziz, J. A. Aguilar- Pimentel, O. V. Amarie, L. Becker, P. da Silva-Buttkus, J. Calzada-Wack, Y.-L. Cho, Y. Deng, A. C. Edwards, L. Garrett, C. Georgopoulou, , Schmidt-Weber

This study uses large-scale phenotyping in mice to show that longevity regulators affect age-sensitive phenotypes before detectable aging begins, rather than slowing aging rates.

bioRxiv · Mar 25, 2022Physiology