Author

O. D. K. Maddocks

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:metabolomics· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Sanz· 2 shared F. Scialo· 2 shared R. Stefanatos· 2 shared A. Acharjee· 1 shared A. Burton· 1 shared A. D. Campbell· 1 shared A. Dexter· 1 shared A. E. H. Yek· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersPhysiology

A. Sanz

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target

J. Vande Voorde, A. K. Najumudeen, R. T. Steven, C. J. Nikula, A. Dexter, L. B. Zeiger, E. A. Elia, A. Nassif, A. Gonzalez-Fernandez, T. Murta, M. Gillespie, C. A. Ford, T. R. M. Lannagan, N. Vlahov, R. A. Ridgway, , O. J. Sansom

This study uses metabolomics to stratify colorectal cancer tissues and identifies adenosylhomocysteinase as a potential therapeutic target.

bioRxiv · Mar 12, 2023Cancer Biology

ROS signalling requires uninterrupted electron flow and is lost during ageing in flies

C. Graham, R. Stefanatos, A. E. H. Yek, R. V. Spriggs, S. H. Y. Loh, A. Huerta Uribe, T. Zhang, L. M. Martins, O. D. K. Maddocks, F. Scialo, A. Sanz

The paper shows that ROS-RET signalling requires uninterrupted electron flow through the ETC and is lost during ageing in flies, leading to persistent mtROS production and reduced stress adaptation.

bioRxiv · Aug 18, 2021 · PreprintPhysiology

Autophagy promotes cell and organismal survival by maintaining NAD(H) pools

L. Sedlackova, E. G. Otten, F. Scialo, D. Shapira, T. Kataura, B. Carroll, E. Seranova, Y. Rabanal Ruiz, G. Kelly, R. Stefanatos, G. Nelson, F. Urselli, A. Acharjee, N. S. Kenneth, S. A. Trushin, , V. I. Korolchuk

This study identifies autophagy's role in maintaining NAD(H) pools, showing that NAD(H) depletion leads to cell death and that NAD(H) supplementation can reverse this effect in autophagy-deficient models.

bioRxiv · Jan 31, 2020 · PreprintCell Biology