P. England

A monoclonal antibody collection for C. difficile typing

The paper develops a monoclonal antibody collection targeting C. difficile strains to improve research on clinically relevant ribotypes.

Anti-S-layer monoclonal antibodies impact Clostridioides difficile physiology

This study identifies monoclonal antibodies targeting C. difficile's S-layer protein, revealing both protective and detrimental effects on bacterial physiology.

Raynals, an online tool for the analysis of dynamic light scattering

Raynals is a software tool for analyzing single-angle DLS data, designed to improve interpretation and quality control of biological samples by simulating data limitations and providing publication-quality outputs.

Molecular mechanisms regulating the pH-dependent pr/E interaction in yellow fever virus.

This study shows that yellow fever virus pr retains high affinity for E at neutral pH, differing from other flaviviruses, and reveals a unique mechanism for pr release from mature particles.

The cell wall lipoprotein CD1687 acts as a DNA binding protein during deoxycholate-induced biofilm formation in Clostridioides difficile

This study identifies CD1687 as a DNA-binding lipoprotein required for DCA-induced biofilm formation in C. difficile by promoting cell-matrix interactions through eDNA binding.

Antigen self-anchoring onto bacteriophage T5 capsid-like particles for vaccine design

This paper develops a vaccine platform using bacteriophage T5 capsid-like particles to display antigens, showing strong immune responses without adjuvants.

Single-cell analyses of immune thrombocytopenic patients reveal multiorgan dissemination of high-affinity autoreactive plasma cells

This study identifies high-affinity autoreactive plasma cells in multiple organs of ITP patients, showing treatment resistance and suggesting therapy failure mechanisms.

The dengue virus NS1 protein conveys pro-inflammatory signals by docking onto human high-density lipoproteins

This study identifies NS1-dengue virus protein's interaction with human HDL as a mechanism to trigger pro-inflammatory signals during infection.

Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA

The paper determines the cryo-EM structure of the PolD-PCNA complex from Pyrococcus abyssi, revealing the molecular basis for increased processivity through PCNA interaction.

Essential dynamic interdependence of FtsZ and SepF for Z-ring and septum formation in Corynebacterium glutamicum

This study investigates the essential interaction between FtsZ and SepF in C. glutamicum, revealing their dynamic roles in Z-ring and septum formation through structural and functional analyses.