Author

P. Clarke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Pharmacology & Toxicology· 2 Ecology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:human· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:drug response / drug discovery· 2 Assay:metagenomics· 2 Assay:whole-genome sequencing· 2

Frequent Co-Authors

C. Alcon-Giner· 4 shared L. J. Hall· 4 shared R. Kiu· 3 shared A. Shaw· 2 shared G. Belteki· 2 shared K. Sim· 2 shared M. Kujawska· 2 shared S. Caim· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersMicrobiology

C. Alcon-Giner

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Partial refuges from biological control due to intraspecific variation in protective host traits: a case study with the egg parasitoid Trissolcus japonicus

P. K. Abram, T. Haye, P. Clarke, E. Grove, J. Thiessen, T. D. Gariepy

The paper investigates how intraspecific variation in host traits affects refuge size for natural enemies, using Trissolcus japonicus and stink bugs as a case study, finding no significant refuge effect on non-target species.

bioRxiv · Apr 28, 2022 · PreprintEcology

A novel bacteriocin produced by Bifidobacterium longum subsp. infantis has dual antimicrobial and immunomodulatory activity

S. G. Javvadi, M. Kujawska, D. Papp, A. M. Gontarczyk, A. Jordan, M. A. Lawson, I. J. O'Neill, C. Alcon-Giner, R. Kiu, P. Clarke, N. Beraza, L. J. Hall

bioRxiv · Jan 27, 2022 · PreprintMicrobiology

Strain dependent structural effects and in vivo efficacy of enterovirus-D68 inhibitors

T. R. Lane, J. Fu, B. Sherry, B. Tarbet, B. Hurst, O. Riabova, E. Kazakova, A. Egorova, P. Clarke, J. S. Leser, J. Frost, M. Rudy, K. Tyler, T. Klose, R. J. Kuhn, , S. Ekins

This study develops a potent EV-D68 inhibitor, 11526092, showing improved in vitro potency and in vivo efficacy compared to pleconaril, with strain-dependent structural effects observed via cryo-EM.

bioRxiv · Dec 24, 2021 · PreprintPharmacology & Toxicology

Dissemination and pathogenesis of toxigenic Clostridium perfringens strains linked to neonatal intensive care units and Necrotising Enterocolitis

R. Kiu, A. Shaw, K. Sim, H. Bedwell, E. Cornwell, D. Pickard, G. Belteki, J. Malsom, S. Philips, G. Young, Z. Schofield, C. Alcon-Giner, J. Berrington, C. Stewart, G. Dougan, , L. J. Hall

This study identifies hypervirulent C. perfringens strains linked to NEC in preterm infants, showing their dissemination between hospitals and increased virulence.

bioRxiv · Aug 3, 2021 · PreprintMicrobiology

Preterm infants harbour diverse Klebsiella populations, including atypical species that encode and produce an array of antimicrobial resistance- and virulence-associated factors

Y. Chen, T. C. Brook, C. Z. Soe, I. O'Neill, C. Alcon-Giner, O. Leelastwattanagul, S. Phillips, S. Caim, P. Clarke, L. J. Hall, L. Hoyles

The paper isolates and characterizes Klebsiella species from preterm infants, revealing diverse species and antimicrobial resistance traits associated with health and disease.

Microbial Genomics · Jun 1, 2020Peer-reviewedMicrobiology

Microbiota supplementation with Bifidobacterium and Lactobacillus modifies the preterm infant gut microbiota and metabolome

C. Alcon-Giner, M. Dalby, S. Caim, J. Ketskemety, A. Shaw, K. Sim, M. Lawson, R. Kiu, C. Leclaire, L. Chalklen, M. Kujawska, S. Mitra, F. Fardus-Reid, G. Belteki, K. Lloyd, , L. J. Hall

This study shows that supplementing preterm infants with Bifidobacterium and Lactobacillus changes their gut microbiota and increases fecal acetate and lactate levels, resembling a full-term infant's gut environment.

bioRxiv · Oct 4, 2019Microbiology

The off-target kinase landscape of clinical PARP inhibitors

A. A. Antolin, M. Ameratunga, U. Banerji, P. Clarke, P. Workman, B. Al-Lazikani

This study identifies the off-target kinase profiles of four FDA-approved PARP inhibitors, revealing unique polypharmacological effects with potential clinical implications.

bioRxiv · Jan 14, 2019Pharmacology & Toxicology

The plasma biomarker soluble SIGLEC-1 is associated with the type I interferon transcriptional signature, ethnic background and renal disease in systemic lupus erythematosus

J. Oliveira, S. Karrar, D. Rainbow, C. Pinder, P. Clarke, A. Rubio Garcia, O. Al-Assar, K. Burling, T. Vyse, L. Wicker, J. Todd, R. Ferreira

This paper develops an immunoassay for sSIGLEC-1, showing its association with IFN signature, ancestry, and renal disease in SLE.

bioRxiv · Feb 19, 2018Immunology