Author

P. M. Elks

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 8 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:zebrafish· 9 Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 5 Research Focus:cell type annotation· 4 Research Focus:cell signaling & trafficking· 3 Assay:imaging· 3 Assay:bulk RNA-seq· 1 Organism:human· 1

Frequent Co-Authors

A. Lewis· 6 shared F. R. Hammond· 3 shared S. A. Renshaw· 3 shared A. H. Meijer· 2 shared C. A. Loynes· 2 shared G. S. Tomlinson· 2 shared H. M. Isles· 2 shared M. Noursadeghi· 2 shared

Activity by Year

2018-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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6 shared papersImmunology

A. Lewis

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Candida spp. suppress neutrophil reactive nitrogen species to evade killing

T. B. Burgess, F. R. Hammond, P. T. Szkuta, A. Lewis, S. Christou, K. A. Bowden, T. Bicanic, L. Prince, K. R. Ayscough, D. G. Partridge, S. A. Johnston, A. M. Condliffe, P. M. Elks

This study shows that Candida spp. suppress neutrophil reactive nitrogen species to evade killing, and restoring RNS via Hif-1 stabilisation improves infection outcomes.

bioRxiv · Nov 2, 2023Immunology

Tribbles1 and Cop1 cooperate to protect the host during in vivo mycobacterial infection

F. R. Hammond, A. Lewis, G. Pollara, G. S. Tomlinson, M. Noursadeghi, E. Kiss-Toth, P. M. Elks

This study identifies Trib1 and Cop1 as immune regulators that protect against mycobacterial infection by modulating macrophage function and inflammation.

bioRxiv · Aug 25, 2023Immunology

An arginase 2 promoter transgenic illuminates anti-inflammatory signalling in zebrafish

F. R. Hammond, A. Lewis, H. E. Anderson, L. G. Williams, A. H. Meijer, G. F. Wiegertjes, P. M. Elks

This study develops a zebrafish transgenic model to investigate anti-inflammatory signaling, showing arginase 2 is expressed in neutrophils during immune challenges.

bioRxiv · Feb 14, 2022 · PreprintImmunology

Hif-1alpha stabilisation is protective against infection in a zebrafish model of co-morbidity

Y. Schild, A. Mohamed, E. J. Wootton, A. Lewis, P. M. Elks

This study shows Hif-1alpha stabilisation protects against tuberculosis infection in zebrafish even when inflammation is present.

bioRxiv · Oct 8, 2019 · PreprintImmunology

Endogenous pioneer neutrophils release NETs during the swarming response in zebrafish

H. M. Isles, C. A. Loynes, N. Hamilton, C. F. Muir, A. Kadochnikova, K. M. Henry, V. Kadirkamanathan, S. A. Renshaw, P. M. Elks

This study shows that endogenous neutrophils in zebrafish release NETs during the swarming response, revealing a potential role for NETosis in driving this process.

bioRxiv · Jun 5, 2019Immunology

Analysis tools to quantify dissemination of pathology in zebrafish larvae

D. R. Stirling, O. Suleyman, E. Gil, P. M. Elks, V. Torraca, M. Noursadeghi, G. S. Tomlinson

The paper develops QuantiFish, an image analysis tool to quantify bacterial load and spatial distribution in zebrafish larvae infected with Mycobacterium marinum.

bioRxiv · May 17, 2019Microbiology

The CXCL12/CXCR4 signalling axis retains neutrophils at inflammatory sites in zebrafish

H. M. Isles, K. D. Herman, A. L. Robertson, C. A. Loynes, L. R. Prince, P. M. Elks, S. A. Renshaw

This study shows that CXCL12/CXCR4 signaling retains neutrophils at inflammatory sites in zebrafish, and its inhibition accelerates inflammation resolution by promoting reverse migration.

bioRxiv · May 3, 2019Immunology

Hif-1α stabilisation polarises macrophages via cyclooxygenase/prostaglandin E2 in vivo

A. Lewis, P. M. Elks

This study shows hypoxia stabilizes Hif-1α, polarizing macrophages via COX/PGE2 to an M1 phenotype in zebrafish and human cells.

bioRxiv · Feb 10, 2019 · PreprintImmunology

Hif-1alpha induced expression of Il-1beta protects against mycobacterial infection in zebrafish

N. V. Ogryzko, A. Lewis, H. L. Wilson, A. H. Meijer, S. A. Renshaw, P. M. Elks

The paper shows that Hif-1alpha increases Il-1beta expression in zebrafish macrophages, enhancing nitric oxide production and protecting against Mycobacterium marinum infection.

bioRxiv · Jul 30, 2018Immunology