Author

A. M. Condliffe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Organism:zebrafish· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Assay:imaging· 1

Frequent Co-Authors

K. A. Bowden· 2 shared L. Prince· 2 shared A. Bernut· 1 shared A. Chandra· 1 shared A. G. Richter· 1 shared A. J. Cadby· 1 shared A. Lewis· 1 shared A.-K. Stark· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCell Biology

K. A. Bowden

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Author profile →

4 papers

Recent·Most cited

Pulses of Class I PI3kinase activity identify the release and recapture of prey from neutrophil phagosomes

C. F. Muir, C. C. Reyes-Aldasoro, F. Ellett, T. Prajsnar, Y. X. Ho, A. Bernut, C. A. Loynes, S. Elworthy, K. A. Bowden, A. J. Cadby, L. Prince, J. S. King, A. M. Condliffe, S. Renshaw

The paper identifies pulsatile Class I PI3K activity on neutrophil phagosomes during bacterial infection, suggesting phagosomes reopen and reclose to release or restart digestion.

bioRxiv · Feb 29, 2024 · PreprintCell Biology

Candida spp. suppress neutrophil reactive nitrogen species to evade killing

T. B. Burgess, F. R. Hammond, P. T. Szkuta, A. Lewis, S. Christou, K. A. Bowden, T. Bicanic, L. Prince, K. R. Ayscough, D. G. Partridge, S. A. Johnston, A. M. Condliffe, P. M. Elks

This study shows that Candida spp. suppress neutrophil reactive nitrogen species to evade killing, and restoring RNS via Hif-1 stabilisation improves infection outcomes.

bioRxiv · Nov 2, 2023Immunology

Mitochondrial fission is increased in macrophages during mROS production in response to S. pneumoniae

M. Mohasin, K. Balbirnie-Cumming, E. Fisk, E. C. Prestwich, C. D. Russell, J. Marshall, C. Pridans, S. P. Allen, P. J. Shaw, K. J. De Vos, C. J. Hill, P. Bullough, A. M. Condliffe, T. J. Mitchell, H. M. Marriott, D. H. Dockrell

This study shows that mitochondrial fission in macrophages increases during mROS production in response to S. pneumoniae, linked to reduced oxidative phosphorylation and enhanced bacterial killing.

bioRxiv · Nov 16, 2021 · PreprintImmunology

PI3Kδ hyper-activation promotes the development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner

A.-K. Stark, A. Chandra, K. Chakraborty, R. Alam, V. Carbonaro, J. Clark, S. Sriskantharajah, G. Bradley, A. G. Richter, E. Banham-Hall, M. R. Clatworthy, S. Nejentsev, J. N. Hamblin, E. M. Hessel, A. M. Condliffe, K. Okkenhaug

This study identifies a PI3Kδ-driven B cell subset in the lungs that worsens Streptococcus pneumoniae infection independently of antibodies, and shows that inhibiting PI3Kδ improves survival.

bioRxiv · Mar 18, 2018Immunology