F. Geissmann

Breast Cancer Macrophage Heterogeneity and Self-renewal are Determined by Spatial Localization

This study identifies spatial localization as a key determinant of macrophage heterogeneity and self-renewal in breast cancer, with implications for therapeutic strategies.

Plasma membrane abundance dictates phagocytic capacity and functional crosstalk in myeloid cells

This study shows that plasma membrane abundance regulates phagocytic capacity and post-phagocytic migration in myeloid cells, with G{beta}4 deficiency leading to increased phagocytosis and altered trafficking.

Distinct adrenal gland macrophages regulate corticosteroid production

This study identifies two distinct adrenal macrophage subsets in mice and shows that foamy macrophages regulate corticosteroid production through cholesterol accumulation.

Early life high fructose exposure disrupts microglia function and impedes neurodevelopment

This study shows that early life high fructose exposure impairs microglia function and neurodevelopment, with GLUT5 deletion reversing these effects.

The macrophage genetic cassette inr/dtor/pvf2 is a nutritional status checkpoint for developmental timing.

The paper identifies a macrophage genetic cassette that regulates developmental timing by controlling steroid hormone biosynthesis in response to nutritional status.

Diet-regulated production of PDGFcc by macrophages controls energy storage

The paper identifies PDGFcc as a diet-regulated macrophage factor that controls energy storage in mammals by acting on adipocytes, independent of inflammation and insulin resistance.

Blood cells of adult Drosophila do not expand, but control survival after bacterial infection by induction of Drosocin around their reservoir at the respiratory epithelia

The paper identifies the largest reservoir of blood cells in adult Drosophila and shows they control survival after bacterial infection by inducing Drosocin expression in surrounding tissues.

IRF4 haploinsufficiency in a family with Whipples disease

This study identifies IRF4 haploinsufficiency as the genetic cause of Whipples disease in a family, showing age-dependent incomplete penetrance and chronic Tw carriage preceding disease onset.